Well-differentiated Liposarcoma/atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2012 Jan 12

PMID 22234501

Citations 12

Authors

Evangelia Piperi

Konstantinos I Tosios

Nikolaos G Nikitakis

Vasileios F Kyriakopoulos

Fotios Tzerbos

Ioannis G Koutlas

Alexandra Sklavounou

Affiliations

Soon will be listed here.

Abstract

Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.

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