Near-Infrared Dyes: Towards Broad-Spectrum Antivirals

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jan 8

PMID 36613629

Authors

Kseniya A Mariewskaya

Maxim S Krasilnikov

Vladimir A Korshun

Alexey V Ustinov

Vera A Alferova

Affiliations

Soon will be listed here.

Abstract

Broad antiviral activity in vitro is known for many organic photosensitizers generating reactive oxygen species under irradiation with visible light. Low tissue penetration of visible light prevents further development of antiviral therapeutics based on these compounds. One possible solution to this problem is the development of photosensitizers with near-infrared absorption (NIR dyes). These compounds found diverse applications in the photodynamic therapy of tumors and bacterial infections, but they are scarcely mentioned as antivirals. In this account, we aimed to evaluate the therapeutic prospects of various NIR-absorbing and singlet oxygen-generating chromophores for the development of broad-spectrum photosensitizing antivirals.

Citing Articles

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.

Ostroumova O, Efimova S Antibiotics (Basel). 2023; 12(12).

PMID: 38136750 PMC: 10741038. DOI: 10.3390/antibiotics12121716.

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death.

Fujii J, Soma Y, Matsuda Y Molecules. 2023; 28(10).

PMID: 37241826 PMC: 10223444. DOI: 10.3390/molecules28104085.

References

Frei A . Metal Complexes, an Untapped Source of Antibiotic Potential?. Antibiotics (Basel). 2020; 9(2). PMC: 7168053. DOI: 10.3390/antibiotics9020090. View

Brilkina A, Dubasova L, Sergeeva E, Pospelov A, Shilyagina N, Shakhova N . Photobiological properties of phthalocyanine photosensitizers Photosens, Holosens and Phthalosens: A comparative in vitro analysis. J Photochem Photobiol B. 2019; 191:128-134. DOI: 10.1016/j.jphotobiol.2018.12.020. View

Ziganshyna S, Szczepankiewicz G, Kuehnert M, Schulze A, Liebert U, Pietsch C . Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In Vitro. Viruses. 2022; 14(6). PMC: 9229166. DOI: 10.3390/v14061301. View

Evans A, Kavanagh K . Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens. J Med Microbiol. 2021; 70(5). PMC: 8289199. DOI: 10.1099/jmm.0.001363. View

Remichkova M, Mukova L, Nikolaeva-Glomb L, Nikolova N, Doumanova L, Mantareva V . Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes. Z Naturforsch C J Biosci. 2016; 72(3-4):123-128. DOI: 10.1515/znc-2016-0119. View

Vigant F, Santos N, Lee B . Broad-spectrum antivirals against viral fusion. Nat Rev Microbiol. 2015; 13(7):426-37. PMC: 4554337. DOI: 10.1038/nrmicro3475. View

Li L, Luo Z, Chen Z, Chen J, Zhou S, Xu P . Enhanced photodynamic efficacy of zinc phthalocyanine by conjugating to heptalysine. Bioconjug Chem. 2012; 23(11):2168-72. DOI: 10.1021/bc3002997. View

Santra M, Owens M, Birch G, Bradley M . Near-Infrared-Emitting Hemicyanines and Their Photodynamic Killing of Cancer Cells. ACS Appl Bio Mater. 2022; 4(12):8503-8508. DOI: 10.1021/acsabm.1c00996. View

Gendrot M, Andreani J, Duflot I, Boxberger M, Bideau M, Mosnier J . Methylene blue inhibits replication of SARS-CoV-2 in vitro. Int J Antimicrob Agents. 2020; 56(6):106202. PMC: 7566888. DOI: 10.1016/j.ijantimicag.2020.106202. View

10.

Lv Z, Jin L, Gao W, Cao Y, Zhang H, Xue D . Novel YOF-Based Theranostic Agents with a Cascade Effect for NIR-II Fluorescence Imaging and Synergistic Starvation/Photodynamic Therapy of Orthotopic Gliomas. ACS Appl Mater Interfaces. 2022; 14(27):30523-30532. DOI: 10.1021/acsami.2c05354. View

11.

Batat P, Cantuel M, Jonusauskas G, Scarpantonio L, Palma A, OShea D . BF2-azadipyrromethenes: probing the excited-state dynamics of a NIR fluorophore and photodynamic therapy agent. J Phys Chem A. 2011; 115(48):14034-9. DOI: 10.1021/jp2077775. View

12.

Mu J, Xiao M, Shi Y, Geng X, Li H, Yin Y . The Chemistry of Organic Contrast Agents in the NIR-II Window. Angew Chem Int Ed Engl. 2021; 61(14):e202114722. DOI: 10.1002/anie.202114722. View

13.

Zhang X, An L, Tian Q, Lin J, Yang S . Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy. J Mater Chem B. 2020; 8(22):4738-4747. DOI: 10.1039/d0tb00030b. View

14.

Baker A, Kanofsky J . Direct observation of singlet oxygen phosphorescence at 1270 nm from L1210 leukemia cells exposed to polyporphyrin and light. Arch Biochem Biophys. 1991; 286(1):70-5. DOI: 10.1016/0003-9861(91)90009-8. View

15.

Yu Z, Wang H, Chen Z, Dong X, Zhao W, Shi Y . Discovery of an Amino Acid-Modified Near-Infrared Aza-BODIPY Photosensitizer as an Immune Initiator for Potent Photodynamic Therapy in Melanoma. J Med Chem. 2022; 65(4):3616-3631. DOI: 10.1021/acs.jmedchem.1c02154. View

16.

Zhou X, Zheng K, Li R, Chen Z, Yuan C, Hu P . A drug carrier targeting murine uPAR for photodynamic therapy and tumor imaging. Acta Biomater. 2015; 23:116-126. DOI: 10.1016/j.actbio.2015.05.017. View

17.

Li B, Liu H, He Y, Zhao M, Ge C, Younis M . A "Self-Checking" pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photothermal Therapy Efficacy. Angew Chem Int Ed Engl. 2022; 61(16):e202200025. DOI: 10.1002/anie.202200025. View

18.

Yano T, Minamide T, Takashima K, Nakajo K, Kadota T, Yoda Y . Clinical Practice of Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer. J Clin Med. 2021; 10(13). PMC: 8268336. DOI: 10.3390/jcm10132785. View

19.

Deckers J, Cardeynaels T, Penxten H, Ethirajan A, Ameloot M, Kruk M . Near-Infrared BODIPY-Acridine Dyads Acting as Heavy-Atom-Free Dual-Functioning Photosensitizers. Chemistry. 2020; 26(66):15212-15225. DOI: 10.1002/chem.202002549. View

20.

Di Mascio P, Martinez G, Miyamoto S, Ronsein G, Medeiros M, Cadet J . Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins. Chem Rev. 2019; 119(3):2043-2086. DOI: 10.1021/acs.chemrev.8b00554. View