Single-cell High-dimensional Imaging Mass Cytometry: One Step Beyond in Oncology

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2023 Jan 4

PMID 36598557

Authors

Yael Glasson

Laure-Agnes Chepeaux

Anne-Sophie Dume

Virginie Lafont

Julien Faget

Nathalie Bonnefoy

Henri-Alexandre Michaud

Affiliations

Soon will be listed here.

Abstract

Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the abundance, localization, and functional orientation of each cell component within the tumor microenvironment vary significantly over time and in response to treatment. Such intratumoral heterogeneity influences the tumor course and its sensitivity to treatments. Recently, high-dimensional imaging mass cytometry (IMC) has been developed to explore the tumor ecosystem at the single-cell level. In the last years, several studies demonstrated that IMC is a powerful tool to decipher the tumor complexity. In this review, we summarize the potential of this technology and how it may be useful for cancer research (from preclinical to clinical studies).

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