Role of Adipocyte Browning in Prostate and Breast Tumor Microenvironment

Overview

Journal Tzu Chi Med J

Specialty General Medicine

Date 2022 Dec 29

PMID 36578640

Authors

Hui-Chen Ku

Ching-Feng Cheng

Affiliations

Soon will be listed here.

Abstract

Prostate cancer (PC) and breast cancer (BC) are the most common cancers in men and women, respectively, in developed countries. The increased incidence of PC and BC largely reflects an increase in the prevalence of obesity and metabolic syndrome. In pathological conditions involving the development and progression of PC and BC, adipose tissue plays an important role via paracrine and endocrine signaling. The increase in the amount of local adipose tissue, specifically periprostatic adipose tissue, may be a key contributor to the PC pathobiology. Similarly, breast adipose tissue secretion affects various aspects of BC by influencing tumor progression, angiogenesis, metastasis, and microenvironment. In this context, the role of white adipose tissue (WAT) has been extensively studied. However, the influence of browning of the WAT on the development and progression of PC and BC is unclear and has received less attention. In this review, we highlight that adipose tissue plays a vital role in the regulation of the tumor microenvironment in PC or BC and highlight the probable underlying mechanisms linking adipose tissue with PC or BC. We further discuss whether the browning of WAT could be a therapeutic strategy for the treatment of PC and BC.

Citing Articles

Genetic associations of polymorphisms with clinicopathologic characteristics of prostate cancer in Taiwanese males.

Hu S, Liu S, Lin C, Fong Y, Wang S, Chen L Int J Med Sci. 2024; 21(13):2494-2501.

PMID: 39439457 PMC: 11492887. DOI: 10.7150/ijms.101020.

References

Tokuda Y, Satoh Y, Fujiyama C, Toda S, Sugihara H, Masaki Z . Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction. BJU Int. 2003; 91(7):716-20. DOI: 10.1046/j.1464-410x.2003.04218.x. View

Zhong S, Yan X, Wu Y, Zhang X, Chen L, Tang J . Body mass index and mortality in prostate cancer patients: a dose-response meta-analysis. Prostate Cancer Prostatic Dis. 2016; 19(2):122-31. DOI: 10.1038/pcan.2015.64. View

Hardy S, Langelier Y, Prentki M . Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res. 2000; 60(22):6353-8. View

Frontini A, Vitali A, Perugini J, Murano I, Romiti C, Ricquier D . White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta. 2013; 1831(5):950-9. DOI: 10.1016/j.bbalip.2013.02.005. View

Guerra C, Koza R, Yamashita H, Walsh K, Kozak L . Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest. 1998; 102(2):412-20. PMC: 508900. DOI: 10.1172/JCI3155. View

Arnold M, Leitzmann M, Freisling H, Bray F, Romieu I, Renehan A . Obesity and cancer: An update of the global impact. Cancer Epidemiol. 2016; 41:8-15. DOI: 10.1016/j.canep.2016.01.003. View

Sacca P, Creydt V, Choi H, Mazza O, Fletcher S, Fernandez Vallone V . Human periprostatic adipose tissue: its influence on prostate cancer cells. Cell Physiol Biochem. 2012; 30(1):113-22. DOI: 10.1159/000339051. View

Li H, Stampfer M, Mucci L, Rifai N, Qiu W, Kurth T . A 25-year prospective study of plasma adiponectin and leptin concentrations and prostate cancer risk and survival. Clin Chem. 2009; 56(1):34-43. PMC: 2858593. DOI: 10.1373/clinchem.2009.133272. View

Heidegger I, Ofer P, Doppler W, Rotter V, Klocker H, Massoner P . Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells. Endocrinology. 2012; 153(10):4633-43. DOI: 10.1210/en.2012-1348. View

10.

Bostrom P, Wu J, Jedrychowski M, Korde A, Ye L, Lo J . A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012; 481(7382):463-8. PMC: 3522098. DOI: 10.1038/nature10777. View

11.

Yao S, Till C, Kristal A, Goodman P, Hsing A, Tangen C . Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control study. Cancer Causes Control. 2011; 22(8):1121-31. PMC: 3139891. DOI: 10.1007/s10552-011-9787-7. View

12.

Yu D, Zhong Y, Li X, Li Y, Li X, Cao J . ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro. Oncotarget. 2015; 6(40):42687-703. PMC: 4767463. DOI: 10.18632/oncotarget.5883. View

13.

Nieman K, Romero I, Van Houten B, Lengyel E . Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 2013; 1831(10):1533-41. PMC: 3742583. DOI: 10.1016/j.bbalip.2013.02.010. View

14.

Laurent V, Guerard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L . Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat Commun. 2016; 7:10230. PMC: 4729927. DOI: 10.1038/ncomms10230. View

15.

Abd Elmageed Z, Yang Y, Thomas R, Ranjan M, Mondal D, Moroz K . Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells. 2014; 32(4):983-97. PMC: 4184251. DOI: 10.1002/stem.1619. View

16.

Chan J, Stampfer M, Giovannucci E, Gann P, Ma J, Wilkinson P . Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998; 279(5350):563-6. DOI: 10.1126/science.279.5350.563. View

17.

Garcia-Estevez L, Moreno-Bueno G . Updating the role of obesity and cholesterol in breast cancer. Breast Cancer Res. 2019; 21(1):35. PMC: 6397485. DOI: 10.1186/s13058-019-1124-1. View

18.

Ribeiro R, Monteiro C, Catalan V, Hu P, Cunha V, Rodriguez A . Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med. 2012; 10:108. PMC: 3523039. DOI: 10.1186/1741-7015-10-108. View

19.

Susa T, Ikaga R, Kajitani T, Iizuka M, Okinaga H, Tamamori-Adachi M . Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells. J Cell Physiol. 2014; 230(7):1594-606. PMC: 6680109. DOI: 10.1002/jcp.24906. View

20.

Parr C, Batty G, Lam T, Barzi F, Fang X, Ho S . Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424,519 participants. Lancet Oncol. 2010; 11(8):741-52. PMC: 4170782. DOI: 10.1016/S1470-2045(10)70141-8. View