Applications and Prospects of Different Functional Hydrogels in Meniscus Repair

Overview

Journal Front Bioeng Biotechnol

Date 2022 Dec 26

PMID 36568293

Authors

Pan Jin

Lei Liu

Xichi Chen

Lin Cheng

Weining Zhang

Gang Zhong

Affiliations

Soon will be listed here.

Abstract

The meniscus is a kind of fibrous cartilage structure that serves as a cushion in the knee joint to alleviate the mechanical load. It is commonly injured, but it cannot heal spontaneously. Traditional meniscectomy is not currently recommended as this treatment tends to cause osteoarthritis. Due to their good biocompatibility and versatile regulation, hydrogels are emerging biomaterials in tissue engineering. Hydrogels are excellent candidates in meniscus rehabilitation and regeneration because they are fine-tunable, easily modified, and capable of delivering exogenous drugs, cells, proteins, and cytokines. Various hydrogels have been reported to work well in meniscus-damaged animals, but few hydrogels are effective in the clinic, indicating that hydrogels possess many overlooked problems. In this review, we summarize the applications and problems of hydrogels in extrinsic substance delivery, meniscus rehabilitation, and meniscus regeneration. This study will provide theoretical guidance for new therapeutic strategies for meniscus repair.

Citing Articles

Advances in bioadhesives for meniscal repair: A comprehensive review and criteria for the ideal candidate.

Mazy D, Jafari A, Savoji H, Nault M J Orthop. 2024; 56:82-86.

PMID: 38800588 PMC: 11127183. DOI: 10.1016/j.jor.2024.05.015.

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives.

Zhou Z, Wang J, Jiang C, Xu K, Xu T, Yu X Gels. 2024; 10(2).

PMID: 38391445 PMC: 10887778. DOI: 10.3390/gels10020114.

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels.

Wu F, Lei N, Yang S, Zhou J, Chen M, Chen C Front Bioeng Biotechnol. 2023; 11:1264006.

PMID: 37720318 PMC: 10501405. DOI: 10.3389/fbioe.2023.1264006.

References

Yamasaki T, Deie M, Shinomiya R, Izuta Y, Yasunaga Y, Yanada S . Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow. J Biomed Mater Res A. 2005; 75(1):23-30. DOI: 10.1002/jbm.a.30369. View

Maisani M, Sindhu K, Fenelon M, Siadous R, Rey S, Mantovani D . Prolonged delivery of BMP-2 by a non-polymer hydrogel for bone defect regeneration. Drug Deliv Transl Res. 2017; 8(1):178-190. DOI: 10.1007/s13346-017-0451-y. View

Das S, Saha D, Majumdar S, Giri L . Imaging Methods for the Assessment of a Complex Hydrogel as an Ocular Drug Delivery System for Glaucoma Treatment: Opportunities and Challenges in Preclinical Evaluation. Mol Pharm. 2022; 19(3):733-748. DOI: 10.1021/acs.molpharmaceut.1c00831. View

Li H, Zhao T, Cao F, Deng H, He S, Li J . Integrated bioactive scaffold with aptamer-targeted stem cell recruitment and growth factor-induced pro-differentiation effects for anisotropic meniscal regeneration. Bioeng Transl Med. 2022; 7(3):e10302. PMC: 9472018. DOI: 10.1002/btm2.10302. View

Chen M, Feng Z, Guo W, Yang D, Gao S, Li Y . PCL-MECM-Based Hydrogel Hybrid Scaffolds and Meniscal Fibrochondrocytes Promote Whole Meniscus Regeneration in a Rabbit Meniscectomy Model. ACS Appl Mater Interfaces. 2019; 11(44):41626-41639. DOI: 10.1021/acsami.9b13611. View

Lan X, Ma Z, Szojka A, Kunze M, Mulet-Sierra A, Vyhlidal M . TEMPO-Oxidized Cellulose Nanofiber-Alginate Hydrogel as a Bioink for Human Meniscus Tissue Engineering. Front Bioeng Biotechnol. 2021; 9:766399. PMC: 8602093. DOI: 10.3389/fbioe.2021.766399. View

Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M . Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. Int J Biol Macromol. 2021; 183:1327-1345. DOI: 10.1016/j.ijbiomac.2021.04.151. View

Wang C, Brisson B, Terajima M, Li Q, Hoxha K, Han B . Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus. Matrix Biol. 2019; 85-86:47-67. PMC: 7137252. DOI: 10.1016/j.matbio.2019.10.001. View

Zhang Z, Guo W, Gao S, Chen M, Li X, Zhang X . Native tissue-based strategies for meniscus repair and regeneration. Cell Tissue Res. 2018; 373(2):337-350. DOI: 10.1007/s00441-017-2778-6. View

10.

Chen S, Fu P, Wu H, Pei M . Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function. Cell Tissue Res. 2017; 370(1):53-70. PMC: 5645221. DOI: 10.1007/s00441-017-2613-0. View

11.

Baysan G, Colpankan Gunes O, Akokay P, Husemoglu R, Ertugruloglu P, Ziylan Albayrak A . Loofah-chitosan and poly (-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) based hydrogel scaffolds for meniscus tissue engineering applications. Int J Biol Macromol. 2022; 221:1171-1183. DOI: 10.1016/j.ijbiomac.2022.09.031. View

12.

Braun H, Wasterlain A, Dragoo J . The use of PRP in ligament and meniscal healing. Sports Med Arthrosc Rev. 2013; 21(4):206-12. DOI: 10.1097/JSA.0000000000000005. View

13.

Wang L, Wang J, Zhou X, Sun J, Zhu B, Duan C . A New Self-Healing Hydrogel Containing hucMSC-Derived Exosomes Promotes Bone Regeneration. Front Bioeng Biotechnol. 2020; 8:564731. PMC: 7521201. DOI: 10.3389/fbioe.2020.564731. View

14.

Perinelli D, Campana R, Skouras A, Bonacucina G, Cespi M, Mastrotto F . Chitosan Loaded into a Hydrogel Delivery System as a Strategy to Treat Vaginal Co-Infection. Pharmaceutics. 2018; 10(1). PMC: 5874836. DOI: 10.3390/pharmaceutics10010023. View

15.

Sthijns M, van Blitterswijk C, LaPointe V . Synthetic Materials that Affect the Extracellular Matrix via Cellular Metabolism and Responses to a Metabolic State. Front Bioeng Biotechnol. 2021; 9:742132. PMC: 8542861. DOI: 10.3389/fbioe.2021.742132. View

16.

Longo U, Loppini M, Forriol F, Romeo G, Maffulli N, Denaro V . Advances in meniscal tissue engineering. Stem Cells Int. 2014; 2012:420346. PMC: 3205710. DOI: 10.1155/2012/420346. View

17.

An Y, Kim J, Yim H, Han W, Park Y, Park H . Meniscus regeneration with injectable Pluronic/PMMA-reinforced fibrin hydrogels in a rabbit segmental meniscectomy model. J Tissue Eng. 2021; 12:20417314211050141. PMC: 8552387. DOI: 10.1177/20417314211050141. View

18.

Liang Y, Idrees E, Szojka A, Andrews S, Kunze M, Mulet-Sierra A . Chondrogenic differentiation of synovial fluid mesenchymal stem cells on human meniscus-derived decellularized matrix requires exogenous growth factors. Acta Biomater. 2018; 80:131-143. DOI: 10.1016/j.actbio.2018.09.038. View

19.

Wu Y, Li X, Sun Y, Tan X, Wang C, Wang Z . Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioact Mater. 2022; 20:111-125. PMC: 9133584. DOI: 10.1016/j.bioactmat.2022.05.021. View

20.

Narita A, Takahara M, Sato D, Ogino T, Fukushima S, Kimura Y . Biodegradable gelatin hydrogels incorporating fibroblast growth factor 2 promote healing of horizontal tears in rabbit meniscus. Arthroscopy. 2011; 28(2):255-63. DOI: 10.1016/j.arthro.2011.08.294. View