Association of Homocysteine and Polymorphism of Methylenetetrahydrofolate Reductase with Early-onset Post Stroke Depression

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Dec 23

PMID 36562046

Authors

Jingyuan Zhang

Chang Zeng

Xia Huang

Qiao Liao

Hengshu Chen

Fan Liu

Dongren Sun

Shihang Luo

Yeqing Xiao

Weiye Xu

Danfeng Zeng

Mingyu Song

Fafa Tian

Affiliations

Soon will be listed here.

Abstract

Background: Homocysteine (Hcy) has been indicated to be involved in pathophysiology of post stroke depression (PSD). There is a lack of research to study the relationship between Hcy metabolism genes and PSD. Our study aims to investigate the relationship among Hcy metabolism genes, Hcy, and early-onset PSD.

Materials And Methods: We recruited 212 patients with stroke and collected their peripheral blood sample, clinical data, and laboratory test on admission. 12 single nucleotide polymorphisms (SNPs) in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methionine synthase (MTR) genes were genotyped by high-resolution melt analysis. PSD was diagnosed by DSM-V at 2 weeks after stroke. Binary logistic regression and haplotype analysis were used to examine the association between Hcy metabolism genes and PSD. Mediation analysis was performed to clarify whether the SNPs exerted their effect on PSD by affecting the Hcy level.

Results: 81 patients were diagnosed with PSD, and the incidence rate was 38.2%. Hcy level in PSD group was significantly higher than it in non-PSD group ( = 0.019). MTHFR rs1801133 AA genotype an A allele were associated with an elevated risk of PSD after adjustment for some confounding factors (OR = 4.021, 95% CI: 1.459∼11.080, = 0.007 for AA genotype; OR = 1.808, 95% CI: 1.172∼2.788, = 0.007 for A allele). Furthermore, the effect of MTHFR rs1801133 AA genotype on PSD was mediated by Hcy (OR = 1.569, 95% CI: 0.013∼3.350, < 0.05).

Conclusion: MTHFR rs1801133 and Hcy were associated with PSD, and MTHFR rs1801133 may exert an effect on PSD mediating Hcy level. This offers a new perspective for treating PSD and understanding the mechanism of PSD.

Citing Articles

Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression.

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Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke.

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Zhou H, Wang C, Wang W, Li H, Hu Q, Huang N Brain Behav. 2023; 13(10):e3210.

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