Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Dec 23

PMID 36557841

Authors

Mithun Rudrapal

Ashwini K Mishra

Laxmi Rani

Khomendra K Sarwa

James H Zothantluanga

Johra Khan

Mehnaz Kamal

Santwana Palai

Atul R Bendale

Swati G Talele

Vasim T Pathan

Laxmikant B Borse

Vishnu S Neharkar

Pravat K Sahoo

Affiliations

Soon will be listed here.

Abstract

Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.

Citing Articles

Extra Virgin Olive Oil Polyphenol-Enriched Extracts Exert Antioxidant and Anti-Inflammatory Effects on Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.

Tamburini B, Di Liberto D, Pratelli G, Rizzo C, Barbera L, Lauricella M Antioxidants (Basel). 2025; 14(2).

PMID: 40002358 PMC: 11851824. DOI: 10.3390/antiox14020171.

A central composite design-based targeted quercetin nanoliposomal formulation: Optimization and cytotoxic studies on MCF-7 breast cancer cell lines.

Bhargav E, Mohammed N, Singh U, Ramalingam P, Challa R, Vallamkonda B Heliyon. 2024; 10(17):e37430.

PMID: 39296160 PMC: 11409131. DOI: 10.1016/j.heliyon.2024.e37430.

Comprehensive overview of how to fade into succinate dehydrogenase dysregulation in cancer cells by naringenin-loaded chitosan nanoparticles.

Ragab E, Khamis A, El Gamal D, Mohamed T Genes Nutr. 2024; 19(1):10.

PMID: 38802732 PMC: 11131324. DOI: 10.1186/s12263-024-00740-x.

Nanomedicine drug delivery in South Africa: a retrospective study on research, funding and collaboration.

Salie F, Saidi T Front Pharmacol. 2024; 14:1317137.

PMID: 38235118 PMC: 10792447. DOI: 10.3389/fphar.2023.1317137.

The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival.

Focaccetti C, Palumbo C, Benvenuto M, Carrano R, Melaiu O, Nardozi D Int J Mol Sci. 2024; 25(1).

PMID: 38203402 PMC: 10779126. DOI: 10.3390/ijms25010232.

References

Javed Z, Khan K, Herrera-Bravo J, Naeem S, Iqbal M, Sadia H . Genistein as a regulator of signaling pathways and microRNAs in different types of cancers. Cancer Cell Int. 2021; 21(1):388. PMC: 8296701. DOI: 10.1186/s12935-021-02091-8. View

Ranjan A, Mukerjee A, Helson L, Gupta R, Vishwanatha J . Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis. Anticancer Res. 2013; 33(9):3603-9. View

Xie Y, Lu Y, Qi J, Li X, Zhang X, Han J . Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy. Int J Pharm. 2012; 441(1-2):111-20. DOI: 10.1016/j.ijpharm.2012.12.007. View

Shangguan M, Lu Y, Qi J, Han J, Tian Z, Xie Y . Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. J Biomater Appl. 2013; 28(6):887-96. DOI: 10.1177/0885328213485141. View

Shao J, Li X, Lu X, Jiang C, Hu Y, Li Q . Enhanced growth inhibition effect of resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levels. Colloids Surf B Biointerfaces. 2009; 72(1):40-7. DOI: 10.1016/j.colsurfb.2009.03.010. View

Ju J, Hong J, Zhou J, Pan Z, Bose M, Liao J . Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res. 2005; 65(22):10623-31. DOI: 10.1158/0008-5472.CAN-05-1949. View

Qian Y, Ramamurthy S, Candasamy M, Shadab M, Kumar R, Meka V . Production, Characterization and Evaluation of Kaempferol Nanosuspension for Improving Oral Bioavailability. Curr Pharm Biotechnol. 2016; 17(6):549-55. DOI: 10.2174/1389201017666160127110609. View

Khan H, Ullah H, Martorell M, Valdes S, Belwal T, Tejada S . Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects. Semin Cancer Biol. 2019; 69:200-211. DOI: 10.1016/j.semcancer.2019.07.023. View

Huang X, Wu Z, Gao W, Chen Q, Yu B . Polyamidoamine dendrimers as potential drug carriers for enhanced aqueous solubility and oral bioavailability of silybin. Drug Dev Ind Pharm. 2010; 37(4):419-27. DOI: 10.3109/03639045.2010.518150. View

10.

Teskac K, Kristl J . The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm. 2009; 390(1):61-9. DOI: 10.1016/j.ijpharm.2009.10.011. View

11.

Desai J, Thakkar H . Effect of particle size on oral bioavailability of darunavir-loaded solid lipid nanoparticles. J Microencapsul. 2016; 33(7):669-678. DOI: 10.1080/02652048.2016.1245363. View

12.

Coimbra M, Isacchi B, van Bloois L, Torano J, Ket A, Wu X . Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes. Int J Pharm. 2011; 416(2):433-42. DOI: 10.1016/j.ijpharm.2011.01.056. View

13.

Faisal W, Soliman G, Hamdan A . Enhanced skin deposition and delivery of voriconazole using ethosomal preparations. J Liposome Res. 2016; 28(1):14-21. DOI: 10.1080/08982104.2016.1239636. View

14.

Anand S, Sowbhagya R, Ansari M, Alzohairy M, Alomary M, Almalik A . Polyphenols and Their Nanoformulations: Protective Effects against Human Diseases. Life (Basel). 2022; 12(10). PMC: 9604961. DOI: 10.3390/life12101639. View

15.

Ding S, Zhang Z, Song J, Cheng X, Jiang J, Jia X . Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. Int J Nanomedicine. 2014; 9:2327-33. PMC: 4026550. DOI: 10.2147/IJN.S60938. View

16.

Wang H, Li X, Yang H, Wang J, Li Q, Qu R . Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin. Int J Pharm. 2020; 578:119133. DOI: 10.1016/j.ijpharm.2020.119133. View

17.

Yuan Z, Chen L, Fan L, Tang M, Yang G, Yang H . Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin Cancer Res. 2006; 12(10):3193-9. DOI: 10.1158/1078-0432.CCR-05-2365. View

18.

Ashtary-Larky D, Rezaei Kelishadi M, Bagheri R, Moosavian S, Wong A, Davoodi S . The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Antioxidants (Basel). 2021; 10(7). PMC: 8300831. DOI: 10.3390/antiox10071015. View

19.

Hussain Y, Mirzaei S, Ashrafizadeh M, Zarrabi A, Hushmandi K, Khan H . Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance. Cancers (Basel). 2021; 13(7). PMC: 8036441. DOI: 10.3390/cancers13071602. View

20.

Alam W, Khan H, Shah M, Cauli O, Saso L . Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing. Molecules. 2020; 25(18). PMC: 7570692. DOI: 10.3390/molecules25184073. View