Eukaryotic Translation Initiation Factor EIF4G2 Opens Novel Paths for Protein Synthesis in Development, Apoptosis and Cell Differentiation

Overview

Journal Cell Prolif

Date 2022 Dec 22

PMID 36547008

Authors

Yudi Liu

Jiuwei Cui

Andrew R Hoffman

Ji-Fan Hu

Affiliations

Soon will be listed here.

Abstract

Protein translation is a critical regulatory event involved in nearly all physiological and pathological processes. Eukaryotic translation initiation factors are dedicated to translation initiation, the most highly regulated stage of protein synthesis. Eukaryotic translation initiation factor 4G2 (eIF4G2, also called p97, NAT1 and DAP5), an eIF4G family member that lacks the binding sites for 5' cap binding protein eIF4E, is widely considered to be a key factor for internal ribosome entry sites (IRESs)-mediated cap-independent translation. However, recent findings demonstrate that eIF4G2 also supports many other translation initiation pathways. In this review, we summarize the role of eIF4G2 in a variety of cap-independent and -dependent translation initiation events. Additionally, we also update recent findings regarding the role of eIF4G2 in apoptosis, cell survival, cell differentiation and embryonic development. These studies reveal an emerging new picture of how eIF4G2 utilizes diverse translational mechanisms to regulate gene expression.

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