The Role of Systemic Dehydration in Vocal Fold Healing: Preliminary Findings

Overview

Journal Laryngoscope Investig Otolaryngol

Publisher Wiley

Specialty Otorhinolaryngology

Date 2022 Dec 22

PMID 36544957

Authors

Anumitha Venkatraman

Jan Hawkins

Robyn McCain

Chenwei Duan

Naila Cannes do Nascimento

Abigail Cox

M Preeti Sivasankar

Affiliations

Soon will be listed here.

Abstract

Rationale: Systemic dehydration negatively alters the expression of vocal fold inflammatory and cell junction markers. These biological changes can have downstream effects on the healing processes of injured vocal folds. In the dermis, reduced hydration prolongs inflammation and delays healing. It is unknown whether this biological effect is observed in vocal fold tissue.

Objective: To investigate the effects of systemic dehydration on vocal fold healing outcomes following acute, bilateral vocal fold injury in a rodent model.

Methods: Eighteen systemic dehydrated and 18 euhydrated adult male Sprague Dawley rats experienced bilateral vocal fold injuries or no injury ( = 9/group). Vocal fold gene expression levels of inflammatory mediators and epithelial cell junction markers were measured 24 h post-injury.

Results: Pro-inflammatory gene markers (; ) were differentially expressed in response to systemic dehydration with vocal fold injury compared to non-injury. Epithelial cell junction markers (, ) also exhibited divergent trends following systemic dehydration, but these data were not statistically significant.

Conclusions: Systemic dehydration may affect cellular vocal fold healing processes within 24 h. These findings lay the groundwork for further investigation of how hydration status can affect vocal fold tissue recovery and influence clinical care.

Citing Articles

Water Versus Electrolyte Rehydration on Vocal Fold Osmotic and Oxidative Stress Gene Expression.

Bailey T, Venkatraman A, Cannes do Nascimento N, Cox A, Sivasankar M Laryngoscope. 2024; 134(11):4636-4641.

PMID: 38979957 PMC: 11466689. DOI: 10.1002/lary.31631.

Nil per os in the management of oropharyngeal dysphagia-exploring the unintended consequences.

Cimoli M, Gibney J, Lim M, Castles J, Dammert P Front Rehabil Sci. 2024; 5:1410023.

PMID: 38957683 PMC: 11217566. DOI: 10.3389/fresc.2024.1410023.

Impact of Rehydration Following Systemic Dehydration on Vocal Fold Gene Expression.

Bailey T, Cannes do Nascimento N, Santos A, Cox A, Sivasankar M Laryngoscope. 2023; 133(12):3499-3505.

PMID: 37345579 PMC: 10739564. DOI: 10.1002/lary.30840.

The role of systemic dehydration in vocal fold healing: Preliminary findings.

Venkatraman A, Hawkins J, McCain R, Duan C, Cannes do Nascimento N, Cox A Laryngoscope Investig Otolaryngol. 2022; 7(6):1936-1942.

PMID: 36544957 PMC: 9764801. DOI: 10.1002/lio2.942.

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