Neurocognitive, Physiological, and Biophysical Effects of Transcranial Alternating Current Stimulation

Overview

Journal Trends Cogn Sci

Date 2022 Dec 21

PMID 36543610

Authors

Miles Wischnewski

Ivan Alekseichuk

Alexander Opitz

Affiliations

Soon will be listed here.

Abstract

Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior. Accordingly, tACS has vast potential for cognitive research and brain disorder therapies. The stimulation generates oscillating electric fields in the brain that can bias neural spike timing, causing changes in local neural oscillatory power and cross-frequency and cross-area coherence. tACS affects cognitive performance by modulating underlying single or nested brain rhythms, local or distal synchronization, and metabolic activity. Clinically, stimulation tailored to abnormal neural oscillations shows promising results in alleviating psychiatric and neurological symptoms. We summarize the findings of tACS mechanisms, its use for cognitive applications, and novel developments for personalized stimulation.

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References

Krause V, Wach C, Sudmeyer M, Ferrea S, Schnitzler A, Pollok B . Cortico-muscular coupling and motor performance are modulated by 20 Hz transcranial alternating current stimulation (tACS) in Parkinson's disease. Front Hum Neurosci. 2014; 7:928. PMC: 3893573. DOI: 10.3389/fnhum.2013.00928. View

Moliadze V, Sierau L, Lyzhko E, Stenner T, Werchowski M, Siniatchkin M . After-effects of 10 Hz tACS over the prefrontal cortex on phonological word decisions. Brain Stimul. 2019; 12(6):1464-1474. DOI: 10.1016/j.brs.2019.06.021. View

Johnson L, Alekseichuk I, Krieg J, Doyle A, Yu Y, Vitek J . Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates. Sci Adv. 2020; 6(36). PMC: 7467690. DOI: 10.1126/sciadv.aaz2747. View

Soleimani G, Kupliki R, Bodurka J, Paulus M, Ekhtiari H . How structural and functional MRI can inform dual-site tACS parameters: A case study in a clinical population and its pragmatic implications. Brain Stimul. 2022; 15(2):337-351. DOI: 10.1016/j.brs.2022.01.008. View

Ozen S, Sirota A, Belluscio M, Anastassiou C, Stark E, Koch C . Transcranial electric stimulation entrains cortical neuronal populations in rats. J Neurosci. 2010; 30(34):11476-85. PMC: 2937280. DOI: 10.1523/JNEUROSCI.5252-09.2010. View

Bahr-Hosseini M, Bikson M . Neurovascular-modulation: A review of primary vascular responses to transcranial electrical stimulation as a mechanism of action. Brain Stimul. 2021; 14(4):837-847. DOI: 10.1016/j.brs.2021.04.015. View

Nguyen J, Deng Y, Reinhart R . Brain-state determines learning improvements after transcranial alternating-current stimulation to frontal cortex. Brain Stimul. 2018; 11(4):723-726. PMC: 6019559. DOI: 10.1016/j.brs.2018.02.008. View

Wischnewski M, Joergensen M, Compen B, Schutter D . Frontal Beta Transcranial Alternating Current Stimulation Improves Reversal Learning. Cereb Cortex. 2020; 30(5):3286-3295. PMC: 7197207. DOI: 10.1093/cercor/bhz309. View

Hoy K, Whitty D, Bailey N, Fitzgerald P . Preliminary investigation of the effects of γ-tACS on working memory in schizophrenia. J Neural Transm (Vienna). 2016; 123(10):1205-12. DOI: 10.1007/s00702-016-1554-1. View

10.

Guerra A, Colella D, Giangrosso M, Cannavacciuolo A, Paparella G, Fabbrini G . Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease. Brain. 2021; 145(1):224-236. DOI: 10.1093/brain/awab257. View

11.

Bikson M, Datta A, Rahman A, Scaturro J . Electrode montages for tDCS and weak transcranial electrical stimulation: role of "return" electrode's position and size. Clin Neurophysiol. 2010; 121(12):1976-8. PMC: 2983105. DOI: 10.1016/j.clinph.2010.05.020. View

12.

Zhang H, Watrous A, Patel A, Jacobs J . Theta and Alpha Oscillations Are Traveling Waves in the Human Neocortex. Neuron. 2018; 98(6):1269-1281.e4. PMC: 6534129. DOI: 10.1016/j.neuron.2018.05.019. View

13.

Fiene M, Schwab B, Misselhorn J, Herrmann C, Schneider T, Engel A . Phase-specific manipulation of rhythmic brain activity by transcranial alternating current stimulation. Brain Stimul. 2020; 13(5):1254-1262. DOI: 10.1016/j.brs.2020.06.008. View

14.

Iaccarino H, Singer A, Martorell A, Rudenko A, Gao F, Gillingham T . Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016; 540(7632):230-235. PMC: 5656389. DOI: 10.1038/nature20587. View

15.

Turner D, Degan S, Galeffi F, Schmidt S, Peterchev A . Rapid, Dose-Dependent Enhancement of Cerebral Blood Flow by transcranial AC Stimulation in Mouse. Brain Stimul. 2020; 14(1):80-87. PMC: 7855527. DOI: 10.1016/j.brs.2020.11.012. View

16.

Khadka N, Borges H, Paneri B, Kaufman T, Nassis E, Zannou A . Adaptive current tDCS up to 4 mA. Brain Stimul. 2019; 13(1):69-79. PMC: 6888879. DOI: 10.1016/j.brs.2019.07.027. View

17.

Huang W, Stitt I, Negahbani E, Passey D, Ahn S, Davey M . Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. Nat Commun. 2021; 12(1):3151. PMC: 8149416. DOI: 10.1038/s41467-021-23021-2. View

18.

Tran H, Shirinpour S, Opitz A . Effects of transcranial alternating current stimulation on spiking activity in computational models of single neocortical neurons. Neuroimage. 2022; 250:118953. PMC: 9087863. DOI: 10.1016/j.neuroimage.2022.118953. View

19.

Wischnewski M, Engelhardt M, Salehinejad M, Schutter D, Kuo M, Nitsche M . NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation. Cereb Cortex. 2018; 29(7):2924-2931. DOI: 10.1093/cercor/bhy160. View

20.

Tseng P, Chang Y, Chang C, Liang W, Juan C . The critical role of phase difference in gamma oscillation within the temporoparietal network for binding visual working memory. Sci Rep. 2016; 6:32138. PMC: 5004173. DOI: 10.1038/srep32138. View