Transcranial Alternating Current Stimulation (tACS) at Gamma Frequency: An up-and-coming Tool to Modify the Progression of Alzheimer's Disease

Overview

Journal Transl Neurodegener

Publisher Biomed Central

Date 2024 Jun 26

PMID 38926897

Authors

Maria Luisa De Paolis

Ilaria Paoletti

Claudio Zaccone

Fioravante Capone

Marcello DAmelio

Paraskevi Krashia

Affiliations

Soon will be listed here.

Abstract

The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer's Disease (AD) and to testing new drugs, with the recent FDA approval of two anti-amyloid monoclonal antibodies for AD treatment. Beyond these drug-based experimentations, a number of pre-clinical and clinical trials are exploring the benefits of alternative treatments, such as non-invasive stimulation techniques on AD neuropathology and symptoms. Among the different non-invasive brain stimulation approaches, transcranial alternating current stimulation (tACS) is gaining particular attention due to its ability to externally control gamma oscillations. Here, we outline the current knowledge concerning the clinical efficacy, safety, ease-of-use and cost-effectiveness of tACS on early and advanced AD, applied specifically at 40 Hz frequency, and also summarise pre-clinical results on validated models of AD and ongoing patient-centred trials.

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