Photobiomodulation in Dental Implant Stability and Post-surgical Healing and Inflammation. A Randomised Double-blind Study

Overview

Journal Clin Oral Implants Res

Specialty Dentistry

Date 2022 Dec 21

PMID 36541106

Authors

Gisela C V Camolesi

Jose M Somoza-Martin

Maria D Reboiras-Lopez

Fabio Camacho-Alonso

Andres Blanco-Carrion

Mario Perez-Sayans

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this randomized clinical trial was to evaluate the effect of diode laser photobiomodulation (PBM) on post-surgical healing, inflammation and implant stability.

Methods: Forty dental implants were inserted into 13 patients. The implants were randomly divided into two groups. The test group (PBM+) underwent two sessions of PBM (combined diode laser of 630 and 808 nm), the first of which after surgery, and the second, 7 days after the surgical procedure. The control group (PBM-) received simulated laser treatment. The implant stability quotient (ISQ) was determined immediately after the surgical procedure, and 7 days, 4 and 8 weeks later. Post-surgical inflammation was assessed following the criteria described by Bloemen and Cols. Healing was calculated using the healing index (HI).

Results: No differences were found in terms of the mean values of implant stability between the test and control groups over time. Only two of the implants (18.2%) from the PBM- group were classified with the maximum healing index (HI = 5), whereas in the PBM+ group, nine implants (45%) were classified with the aforementioned index (P < 0.0001). Using the logistic regression, it was determined that the non-application of the laser in the PBM- group caused an OR of 4.333 times of presenting inflammation (IC95% 1.150-16.323; P = 0.030).

Conclusions: The application of 808 nm infra-red laser for bone tissue, and 630 nm for mucosal tissue in two sessions is considered to be an effective way of reducing inflammation and improving early healing. More studies are needed to confirm these results.

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References

Mandrekar J . Measures of interrater agreement. J Thorac Oncol. 2010; 6(1):6-7. DOI: 10.1097/JTO.0b013e318200f983. View

Farivar S, Malekshahabi T, Shiari R . Biological effects of low level laser therapy. J Lasers Med Sci. 2015; 5(2):58-62. PMC: 4291815. View

Elias C, Rocha F, Nascimento A, Coelho P . Influence of implant shape, surface morphology, surgical technique and bone quality on the primary stability of dental implants. J Mech Behav Biomed Mater. 2012; 16:169-80. DOI: 10.1016/j.jmbbm.2012.10.010. View

Lima A, da Silva Sergio L, da Fonseca A . Photobiomodulation via multiple-wavelength radiations. Lasers Med Sci. 2019; 35(2):307-316. DOI: 10.1007/s10103-019-02879-1. View

Na S, TruongVo T, Jiang F, Joll J, Guo Y, Utreja A . Dose analysis of photobiomodulation therapy on osteoblast, osteoclast, and osteocyte. J Biomed Opt. 2018; 23(7):1-8. DOI: 10.1117/1.JBO.23.7.075008. View

Agha-Hosseini F, Moslemi E, Mirzaii-Dizgah I . Comparative evaluation of low-level laser and CO₂ laser in treatment of patients with oral lichen planus. Int J Oral Maxillofac Surg. 2012; 41(10):1265-9. DOI: 10.1016/j.ijom.2012.06.001. View

Garcia-Morales J, Tortamano-Neto P, Todescan F, de Andrade Jr J, Marotti J, Zezell D . Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study. Lasers Med Sci. 2011; 27(4):703-11. DOI: 10.1007/s10103-011-0948-4. View

Santinoni C, Neves A, Almeida B, Kajimoto N, Pola N, Caliente E . Bone marrow coagulated and low-level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization. J Biomed Mater Res A. 2020; 109(6):849-858. DOI: 10.1002/jbm.a.37076. View

Gokmenoglu C, Ozmeric N, Erguder I, Elgun S . The effect of light-emitting diode photobiomodulation on implant stability and biochemical markers in peri-implant crevicular fluid. Photomed Laser Surg. 2014; 32(3):138-45. DOI: 10.1089/pho.2012.3473. View

10.

Hamzani Y, Chaushu G . Evaluation of early wound healing scales/indexes in oral surgery: A literature review. Clin Implant Dent Relat Res. 2018; 20(6):1030-1035. DOI: 10.1111/cid.12680. View

11.

Monje A, Ravida A, Wang H, Helms J, Brunski J . Relationship Between Primary/Mechanical and Secondary/Biological Implant Stability. Int J Oral Maxillofac Implants. 2019; 34:s7-s23. DOI: 10.11607/jomi.19suppl.g1. View

12.

Palled V, Rao J, Singh R, Tripathi S, Singh K, Radav R . Assessment of the Healing of Dental Implant Surgical Site Following Low-Level Laser Therapy Using Bioclinical Parameters: An Exploratory Study. J Oral Implantol. 2020; 47(3):230-235. DOI: 10.1563/aaid-joi-D-18-00316. View

13.

Monea A, Beresescu G, Boeriu S, Tibor M, Popsor S, Antonescu D . Bone healing after low-level laser application in extraction sockets grafted with allograft material and covered with a resorbable collagen dressing: a pilot histological evaluation. BMC Oral Health. 2015; 15:134. PMC: 4625559. DOI: 10.1186/s12903-015-0122-7. View

14.

Bloemen M, Boekema B, Vlig M, van Zuijlen P, Middelkoop E . Digital image analysis versus clinical assessment of wound epithelialization: a validation study. Burns. 2012; 38(4):501-5. DOI: 10.1016/j.burns.2012.02.003. View

15.

Woodruff L, Bounkeo J, Brannon W, Dawes K, Barham C, Waddell D . The efficacy of laser therapy in wound repair: a meta-analysis of the literature. Photomed Laser Surg. 2004; 22(3):241-7. DOI: 10.1089/1549541041438623. View

16.

Lobato R, de Azevedo Kinalski M, Martins T, Agostini B, Bergoli C, Santos M . Influence of low-level laser therapy on implant stability in implants placed in fresh extraction sockets: A randomized clinical trial. Clin Implant Dent Relat Res. 2020; 22(3):261-269. DOI: 10.1111/cid.12904. View

17.

Chen Y, Liu C, Chen X, Mo A . Clinical evidence of photobiomodulation therapy (PBMT) on implant stability and success: a systematic review and meta-analysis. BMC Oral Health. 2019; 19(1):77. PMC: 6505209. DOI: 10.1186/s12903-019-0779-4. View

18.

Gholami L, Asefi S, Hooshyarfard A, Sculean A, Romanos G, Aoki A . Photobiomodulation in Periodontology and Implant Dentistry: Part 2. Photobiomodul Photomed Laser Surg. 2019; 37(12):766-783. DOI: 10.1089/photob.2019.4731. View

19.

Shokri M, Daraeighadikolaei A . Measurement of primary and secondary stability of dental implants by resonance frequency analysis method in mandible. Int J Dent. 2013; 2013:506968. PMC: 3666244. DOI: 10.1155/2013/506968. View

20.

Karakaya M, Demirbas A . Effect of low-level laser therapy on osseointegration of titanium dental implants in ovariectomized rabbits: biomechanics and micro-CT analysis. Int J Implant Dent. 2020; 6(1):61. PMC: 7548265. DOI: 10.1186/s40729-020-00257-z. View