» Articles » PMID: 36532541

Gut Microbiota in Ischemic Stroke: Where We Stand and Challenges Ahead

Overview
Journal Front Nutr
Date 2022 Dec 19
PMID 36532541
Authors
Affiliations
Soon will be listed here.
Abstract

Gut microbiota is increasingly recognized to affect host health and disease, including ischemic stroke (IS). Here, we systematically review the current understanding linking gut microbiota as well as the associated metabolites to the pathogenesis of IS (e.g., oxidative stress, apoptosis, and neuroinflammation). Of relevance, we highlight that the implications of gut microbiota-dependent intervention could be harnessed in orchestrating IS.

Citing Articles

Vitamin K Properties in Stroke and Alzheimer's Disease: A Janus Bifrons in Protection and Prevention.

Grimaldi L, Cavallaro R, De Angelis D, Fuso A, Sancesario G Molecules. 2025; 30(5).

PMID: 40076254 PMC: 11901974. DOI: 10.3390/molecules30051027.


Electroacupuncture Promotes the Generation of Intestinal Treg Cells After Ischemic Stroke by Foxp3 Acetylation Regulation.

Chen Y, Ouyang L, Yang X, Wu B, Meng L, Gu J Mol Neurobiol. 2024; 62(3):3697-3711.

PMID: 39322831 DOI: 10.1007/s12035-024-04500-1.


Genetically supported causality between gut microbiota, immune cells, and ischemic stroke: a two-sample Mendelian randomization study.

Shuai H, Wang Z, Xiao Y, Ge Y, Mao H, Gao J Front Microbiol. 2024; 15:1402718.

PMID: 38894965 PMC: 11185428. DOI: 10.3389/fmicb.2024.1402718.


Role of the gut microbiota in complications after ischemic stroke.

Zhang J, Ling L, Xiang L, Li W, Bao P, Yue W Front Cell Infect Microbiol. 2024; 14:1334581.

PMID: 38644963 PMC: 11026644. DOI: 10.3389/fcimb.2024.1334581.


Intestinal microbiota modulates neuroinflammatory response and brain injury after neonatal hypoxia-ischemia.

Drobyshevsky A, Synowiec S, Goussakov I, Fabres R, Lu J, Caplan M Gut Microbes. 2024; 16(1):2333808.

PMID: 38533575 PMC: 10978030. DOI: 10.1080/19490976.2024.2333808.

References
1.
Jones R, Desai C, Darby T, Luo L, Wolfarth A, Scharer C . Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Cell Rep. 2015; 12(8):1217-25. PMC: 4640184. DOI: 10.1016/j.celrep.2015.07.042. View

2.
Prabhakaran S, Ruff I, Bernstein R . Acute stroke intervention: a systematic review. JAMA. 2015; 313(14):1451-62. DOI: 10.1001/jama.2015.3058. View

3.
Logsdon A, Erickson M, Rhea E, Salameh T, Banks W . Gut reactions: How the blood-brain barrier connects the microbiome and the brain. Exp Biol Med (Maywood). 2017; 243(2):159-165. PMC: 5788145. DOI: 10.1177/1535370217743766. View

4.
Fann D, Lee S, Manzanero S, Chunduri P, Sobey C, Arumugam T . Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res Rev. 2013; 12(4):941-66. DOI: 10.1016/j.arr.2013.09.004. View

5.
White S, Brisson C, Andrew R . Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons. J Neurophysiol. 2012; 107(8):2083-95. DOI: 10.1152/jn.00701.2011. View