Glucagon-like Peptide-2 Analogues for Crohn's Disease Patients with Short Bowel Syndrome and Intestinal Failure

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2022 Dec 12

PMID 36504557

Authors

Marco Pizzoferrato

Pierluigi Puca

Sara Ennas

Giovanni Cammarota

Luisa Guidi

Affiliations

Soon will be listed here.

Abstract

Short bowel syndrome (SBS) with intestinal failure (IF) is a rare but severe complication of Crohn's disease (CD), which is the most frequent benign condition that leads to SBS after repeated surgical resections, even in the era of biologics and small molecules. Glucagon-like peptide-2 analogues have been deeply studied recently for the treatment of SBS-IF. These drugs have a significant intestinotrophic effect and the potential to reduce the chronic dependence of SBS-IF patients on parenteral support or nutrition. Teduglutide has been approved for the treatment of SBS-IF, and apraglutide is currently in clinical development. The use of these drugs was examined with a focus on their use in CD patients.

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References

Dibb M, Soop M, Teubner A, Shaffer J, Abraham A, Carlson G . Survival and nutritional dependence on home parenteral nutrition: Three decades of experience from a single referral centre. Clin Nutr. 2016; 36(2):570-576. DOI: 10.1016/j.clnu.2016.01.028. View

Martchenko S, Sweeney M, Dimitriadou V, Murray J, Brubaker P . Site-Specific and Temporal Effects of Apraglutide, a Novel Long-Acting Glucagon-Like Peptide-2 Receptor Agonist, on Intestinal Growth in Mice. J Pharmacol Exp Ther. 2020; 373(3):347-352. DOI: 10.1124/jpet.119.263947. View

Buchman A, Moukarzel A . Metabolic bone disease associated with total parenteral nutrition. Clin Nutr. 2000; 19(4):217-31. DOI: 10.1054/clnu.1999.0083. View

Kochar B, Long M, Shelton E, Young L, Farraye F, Yajnik V . Safety and Efficacy of Teduglutide (Gattex) in Patients With Crohn's Disease and Need for Parenteral Support Due to Short Bowel Syndrome-associated Intestinal Failure. J Clin Gastroenterol. 2016; 51(6):508-511. PMC: 5243925. DOI: 10.1097/MCG.0000000000000604. View

Billiauws L, Bataille J, Boehm V, Corcos O, Joly F . Teduglutide for treatment of adult patients with short bowel syndrome. Expert Opin Biol Ther. 2017; 17(5):623-632. DOI: 10.1080/14712598.2017.1304912. View

DiBaise J, Young R, Vanderhoof J . Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome. Clin Gastroenterol Hepatol. 2006; 4(1):11-20. DOI: 10.1016/j.cgh.2005.10.020. View

Warner B . The Pathogenesis of Resection-Associated Intestinal Adaptation. Cell Mol Gastroenterol Hepatol. 2016; 2(4):429-438. PMC: 5042605. DOI: 10.1016/j.jcmgh.2016.05.001. View

Seidner D, Fujioka K, Boullata J, Iyer K, Lee H, Ziegler T . Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Patients With Short Bowel Syndrome-Associated Intestinal Failure: STEPS-3 Study. Nutr Clin Pract. 2018; 33(4):520-527. DOI: 10.1002/ncp.10092. View

Pironi L, Sasdelli A . Intestinal Failure-Associated Liver Disease. Clin Liver Dis. 2019; 23(2):279-291. DOI: 10.1016/j.cld.2018.12.009. View

10.

Dreesen M, Foulon V, Spriet I, Goossens G, Hiele M, De Pourcq L . Epidemiology of catheter-related infections in adult patients receiving home parenteral nutrition: a systematic review. Clin Nutr. 2012; 32(1):16-26. DOI: 10.1016/j.clnu.2012.08.004. View

11.

Hvistendahl M, Naimi R, Hansen S, Rehfeld J, Kissow H, Pedersen J . Bile acid-farnesoid X receptor-fibroblast growth factor 19 axis in patients with short bowel syndrome: The randomized, glepaglutide phase 2 trial. JPEN J Parenter Enteral Nutr. 2021; 46(4):923-935. DOI: 10.1002/jpen.2224. View

12.

Hinchliffe T, Pauline M, Wizzard P, Nation P, Brubaker P, Campbell J . Durability of Linear Small-Intestinal Growth Following Treatment Discontinuation of Long-Acting Glucagon-Like Peptide 2 (GLP-2) Analogues. JPEN J Parenter Enteral Nutr. 2020; 45(7):1466-1474. DOI: 10.1002/jpen.2053. View

13.

Vaillant S, Guillo L, Michot N, DAmico F, Germain A, Danese S . Predictors for short bowel syndrome in Crohn's disease. Dig Liver Dis. 2020; 52(12):1455-1460. DOI: 10.1016/j.dld.2020.08.029. View

14.

Pauline M, Nation P, Wizzard P, Hinchliffe T, Wu T, Dimitriadou V . Comparing the Intestinotrophic Effects of 2 Glucagon-Like Peptide-2 Analogues in the Treatment of Short-Bowel Syndrome in Neonatal Piglets. JPEN J Parenter Enteral Nutr. 2020; 45(3):538-545. DOI: 10.1002/jpen.1853. View

15.

Seiler K, Goo W, Zhang Q, Courtney C, Bajinting A, Guo J . Adaptation of extracellular matrix to massive small bowel resection in mice. J Pediatr Surg. 2020; 55(6):1107-1112. PMC: 7299777. DOI: 10.1016/j.jpedsurg.2020.02.038. View

16.

Schwartz L, OKeefe S, Fujioka K, Gabe S, Lamprecht G, Pape U . Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome. Clin Transl Gastroenterol. 2016; 7:e142. PMC: 4817413. DOI: 10.1038/ctg.2015.69. View

17.

Thomas R, Hellmich M, Townsend Jr C, Evers B . Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues. Endocr Rev. 2003; 24(5):571-99. DOI: 10.1210/er.2002-0028. View

18.

Billiauws L, Joly F . Emerging treatments for short bowel syndrome in adult patients. Expert Rev Gastroenterol Hepatol. 2019; 13(3):241-246. DOI: 10.1080/17474124.2019.1569514. View

19.

Buchman A, Scolapio J, Fryer J . AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology. 2003; 124(4):1111-34. DOI: 10.1016/s0016-5085(03)70064-x. View

20.

Mazzuoli S, Regano N, Lamacchia S, Silvestri A, Guglielmi F . Intestinal iatrogenic hyperadaptation in patients with short bowel syndrome and Crohn's disease: Is this an indication for mandatory lifelong injections of teduglutide?. Nutrition. 2021; 91-92:111396. DOI: 10.1016/j.nut.2021.111396. View