Growth Hormone-Releasing Hormone in Endothelial Inflammation

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2022 Dec 12

PMID 36503995

Authors

Nektarios Barabutis

Mohammad S Akhter

Khadeja-Tul Kubra

Keith Jackson

Affiliations

Soon will be listed here.

Abstract

The discovery of hypothalamic hormones propelled exciting advances in pharmacotherapy and improved life quality worldwide. Growth hormone-releasing hormone (GHRH) is a crucial element in homeostasis maintenance, and regulates the release of growth hormone from the anterior pituitary gland. Accumulating evidence suggests that this neuropeptide can also promote malignancies, as well as inflammation. Our review is focused on the role of that 44 - amino acid peptide (GHRH) and its antagonists in inflammation and vascular function, summarizing recent findings in the corresponding field. Preclinical studies demonstrate the protective role of GHRH antagonists against endothelial barrier dysfunction, suggesting that the development of those peptides may lead to new therapies against pathologies related to vascular remodeling (eg, sepsis, acute respiratory distress syndrome). Targeted therapies for those diseases do not exist.

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