Hubbing the Cancer Cell

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Dec 11

PMID 36497405

Authors

Jingkai Zhou

Matthieu Corvaisier

Darina Malycheva

Maria Alvarado-Kristensson

Affiliations

Soon will be listed here.

Abstract

Oncogenic transformation drives adaptive changes in a growing tumor that affect the cellular organization of cancerous cells, resulting in the loss of specialized cellular functions in the polarized compartmentalization of cells. The resulting altered metabolic and morphological patterns are used clinically as diagnostic markers. This review recapitulates the known functions of actin, microtubules and the γ-tubulin meshwork in orchestrating cell metabolism and functional cellular asymmetry.

Citing Articles

Molecular characterization of the TUBG1 meshwork's influence on Cytoskeletal organization.

Malycheva D, Alvarado-Kristensson M Heliyon. 2025; 11(2):e41829.

PMID: 40013266 PMC: 11862694. DOI: 10.1016/j.heliyon.2025.e41829.

Centrosome Movements Are TUBG1-Dependent.

Malycheva D, Alvarado-Kristensson M Int J Mol Sci. 2023; 24(17).

PMID: 37685969 PMC: 10488117. DOI: 10.3390/ijms241713154.

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