The Emerging Role of Epigenetic Regulation in the Progression of Silicosis

Overview

Journal Clin Epigenetics

Publisher Biomed Central

Specialty Genetics

Date 2022 Dec 10

PMID 36494831

Authors

Haoyu Yin

Yujia Xie

Pei Gu

Wei Li

Yingdie Zhang

Yuxin Yao

Weihong Chen

Jixuan Ma

Affiliations

Soon will be listed here.

Abstract

Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at present. Therefore, elucidating the pathogenesis of silicosis plays a significant guiding role for its treatment and prevention. The occurrence and development of silicosis are accompanied by many regulatory mechanisms, including epigenetic regulation. The main epigenetic regulatory mechanisms of silicosis include DNA methylation, non-coding RNA (ncRNA), and histone modifications. In recent years, the expression and regulation of genes related to silicosis have been explored at epigenetic level to reveal its pathogenesis further, and the identification of aberrant epigenetic markers provides new biomarkers for prediction and diagnosis of silicosis. Here, we summarize the studies on the role of epigenetic changes in the pathogenesis of silicosis to give some clues for finding specific therapeutic targets for silicosis.

Citing Articles

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