Integrative Analysis of Platelet-related Genes for the Prognosis of Esophageal Cancer

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2022 Dec 9

PMID 36483802

Authors

Qian-Cheng Du

Xin-Yu Wang

Cheng-Kai Hu

Ling Zhou

Zheng Fu

Shun Liu

Jian Wang

Ying-Ying Ma

Meng-Yao Liu

Hua Yu

Affiliations

Soon will be listed here.

Abstract

Background: Every year, esophageal cancer is responsible for 509000 deaths and around 572000 new cases worldwide. Although esophageal cancer treatment options have advanced, patients still have a dismal 5-year survival rate.

Aim: To investigate the relationship between genes associated to platelets and the prognosis of esophageal cancer.

Methods: We searched differentially expressed genes for changes between 151 tumor tissues and 653 normal, healthy tissues using the "limma" package. To develop a prediction model of platelet-related genes, a univariate Cox regression analysis and least absolute shrinkage and selection operator Cox regression analysis were carried out. Based on a median risk score, patients were divided into high-risk and low-risk categories. A nomogram was created to predict the 1-, 2-, and 3-year overall survival (OS) of esophageal cancer patients using four platelet-related gene signatures, TNM stages, and pathological type. Additionally, the concordance index, receiver operating characteristic curve, and calibration curve were used to validate the nomogram.

Results: The prognosis of esophageal cancer was associated to , , , and according to univariate Cox regression analysis and least absolute shrinkage and selection operator regression analysis. Patients with esophageal cancer at high risk had substantially shorter OS than those with cancer at low risk, according to a Kaplan-Meier analysis ( < 0.05). TNM stage (hazard ratio: 2.187, 95% confidence interval: 1.242-3.852, = 0.007) in both univariate and multivariate Cox regression and risk score were independently correlated with OS (hazard ratio: 2.451, 95% confidence interval: 1.599-3.756, 0.001).

Conclusion: A survival risk score model and independent prognostic variables for esophageal cancer have been developed using , , , and . OS for esophageal cancer might be predicted using the nomogram based on TNM stage, pathological type, and risk score. The nomogram demonstrated strong predictive ability, as shown by the concordance index, receiver operating characteristic curve, and calibration curve.

Citing Articles

A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma.

Wei S, Zhou J, Dong B Hereditas. 2024; 161(1):52.

PMID: 39707577 PMC: 11662788. DOI: 10.1186/s41065-024-00355-7.

Characterization of platelet-related genes and constructing signature combined with immune-related genes for predicting outcomes and immunotherapy response in lung squamous cell carcinoma.

Zhao S, Gong H, Liang W Aging (Albany NY). 2023; 15(14):6969-6992.

PMID: 37477536 PMC: 10415560. DOI: 10.18632/aging.204886.

References

Baba Y, Nomoto D, Okadome K, Ishimoto T, Iwatsuki M, Miyamoto Y . Tumor immune microenvironment and immune checkpoint inhibitors in esophageal squamous cell carcinoma. Cancer Sci. 2020; 111(9):3132-3141. PMC: 7469863. DOI: 10.1111/cas.14541. View

Lindhiem O, Petersen I, Mentch L, Youngstrom E . The Importance of Calibration in Clinical Psychology. Assessment. 2018; 27(4):840-854. PMC: 6778000. DOI: 10.1177/1073191117752055. View

Li J, Huang C, Xiong T, Zhuang C, Zhuang C, Li Y . A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells . Int J Biol Sci. 2019; 15(6):1276-1286. PMC: 6567804. DOI: 10.7150/ijbs.32332. View

Okuda Y, Shimura T, Iwasaki H, Fukusada S, Nishigaki R, Kitagawa M . Urinary microRNA biomarkers for detecting the presence of esophageal cancer. Sci Rep. 2021; 11(1):8508. PMC: 8058072. DOI: 10.1038/s41598-021-87925-1. View

Bang K, Na Y, Wook Huh H, Hwang S, Kim M, Kim M . The Delivery Strategy of Paclitaxel Nanostructured Lipid Carrier Coated with Platelet Membrane. Cancers (Basel). 2019; 11(6). PMC: 6627627. DOI: 10.3390/cancers11060807. View

Du C, Huang D, Peng Y, Yao Y, Zhao Y, Yang Y . 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. Cancer Lett. 2017; 400:183-193. DOI: 10.1016/j.canlet.2017.04.033. View

Alsamri H, Hasasna H, Baby B, Alneyadi A, Dhaheri Y, Ayoub M . Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer. Front Oncol. 2021; 11:664403. PMC: 8155611. DOI: 10.3389/fonc.2021.664403. View

Lv J, Guo L, Liu J, Zhao H, Zhang J, Wang J . Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma. World J Gastroenterol. 2019; 25(18):2149-2161. PMC: 6526156. DOI: 10.3748/wjg.v25.i18.2149. View

Liu H, Zhang Z, Huang Y, Wei W, Ning S, Li J . Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis. Front Cell Dev Biol. 2021; 9:639596. PMC: 8181396. DOI: 10.3389/fcell.2021.639596. View

10.

Zhang T, Nie Y, Xia H, Zhang Y, Cai K, Chen X . Identification of Immune-Related Prognostic Genes and LncRNAs Biomarkers Associated With Osteosarcoma Microenvironment. Front Oncol. 2020; 10:1109. PMC: 7393189. DOI: 10.3389/fonc.2020.01109. View

11.

Wang Y, Zhi Q, Wang X, Yue D, Li K, Jiang R . Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncol Lett. 2017; 14(4):4331-4338. PMC: 5594242. DOI: 10.3892/ol.2017.6660. View

12.

Yang J, Xu H, Guo X, Zhang J, Ye X, Yang Y . Pretreatment Inflammatory Indexes as Prognostic Predictors for Survival in Colorectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy. Sci Rep. 2018; 8(1):3044. PMC: 5813153. DOI: 10.1038/s41598-018-21093-7. View

13.

Wang X, Kutschat A, Yamada M, Prokakis E, Bottcher P, Tanaka K . Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas. Cell Death Differ. 2021; 28(7):2207-2220. PMC: 8257622. DOI: 10.1038/s41418-021-00751-w. View

14.

Xu S, Zhou Y, Biekemitoufu H, Wang H, Li C, Zhang W . Expression of Twist, Slug and Snail in esophageal squamous cell carcinoma and their prognostic significance. Oncol Lett. 2021; 21(3):184. PMC: 7816285. DOI: 10.3892/ol.2021.12445. View

15.

Zhu L, Dong L, Feng M, Yang F, Jiang W, Huang Z . Profiles of autophagy-related genes in esophageal adenocarcinoma. BMC Cancer. 2020; 20(1):943. PMC: 7528598. DOI: 10.1186/s12885-020-07416-w. View

16.

Han D, Zhang J, Zhao J, Lei T, Chen X, Zhang T . Platelet-to-lymphocyte ratio is an independent predictor of chemoradiotherapy-related esophageal fistula in esophageal cancer patients. Ann Transl Med. 2020; 8(18):1163. PMC: 7576074. DOI: 10.21037/atm-20-4053. View

17.

Yan M, Hou X, Cai B, Qu B, Dai X, Liu F . Neoadjuvant chemoradiotherapy plus surgery in the treatment of potentially resectable thoracic esophageal squamous cell carcinoma. World J Clin Cases. 2021; 8(24):6315-6321. PMC: 7760436. DOI: 10.12998/wjcc.v8.i24.6315. View

18.

Chen L, Zeng H, Yang J, Lu Y, Zhang D, Wang J . Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma. BMC Cancer. 2018; 18(1):816. PMC: 6090788. DOI: 10.1186/s12885-018-4730-x. View

19.

Cui M, Liang Z, Sun Y, Wu J, Lu H, Wang W . The prognostic roles of red blood cell-associated indicators in patients with resectable gastric cancers. Transl Cancer Res. 2022; 9(4):2300-2311. PMC: 8797860. DOI: 10.21037/tcr.2020.03.46. View

20.

Li F, Wang L, Zhang Y, Feng W, Ju T, Liu Z . A Retrospective Study on Using a Novel Single Needle Cone Puncture Approach for the Iodine-125 Seed Brachytherapy in Treating Patients With Thoracic Malignancy. Front Oncol. 2021; 11:640131. PMC: 8200774. DOI: 10.3389/fonc.2021.640131. View