Fatty Acids Derived from the Probiotic Lacticaseibacillus Rhamnosus HA-114 Suppress Age-dependent Neurodegeneration

Overview

Journal Commun Biol

Specialty Biology

Date 2022 Dec 8

PMID 36477191

Authors

Audrey Labarre

Ericka Guitard

Gilles Tossing

Anik Forest

Eric Bareke

Marjorie Labrecque

Martine Tetreault

Matthieu Ruiz

J Alex Parker

Affiliations

Soon will be listed here.

Abstract

The human microbiota is believed to influence health. Microbiome dysbiosis may be linked to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. We report the ability of a probiotic bacterial strain in halting neurodegeneration phenotypes. We show that Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of amyotrophic lateral sclerosis and Huntington's disease. Our results show that neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains and resides in its fatty acid content. Neuroprotection by L. rhamnosus HA-114 requires acdh-1/ACADSB, kat-1/ACAT1 and elo-6/ELOVL3/6, which are associated with fatty acid metabolism and mitochondrial β-oxidation. Our data suggest that disrupted lipid metabolism contributes to neurodegeneration and that dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial β-oxidation. Our findings encourage the exploration of L. rhamnosus HA-114 derived interventions to modify the progression of neurodegenerative diseases.

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