Genetic and Microbiome Influence on Lipid Metabolism and Dyslipidemia

Overview

Journal Physiol Genomics

Publisher American Physiological Society

Specialties Genetics
Molecular Biology

Date 2018 Jan 18

PMID 29341867

Citations 57

Authors

Maria Luisa Matey-Hernandez

Frances M K Williams

Tilly Potter

Ana M Valdes

Tim D Spector

Cristina Menni

Affiliations

Soon will be listed here.

Abstract

Disruption in the metabolism of lipids is broadly classified under dyslipidemia and relates to the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic disease including obesity. Traditionally, the large interindividual variation has been related to genetic factors and diet. Genome-wide association studies have identified over 150 loci related to abnormal lipid levels, explaining ~40% of the total variation. Part of the unexplained variance has been attributed to environmental factors including diet, but the extent of the dietary contribution remains unquantified. Furthermore, other factors are likely to influence lipid metabolism including the gut microbiome, which plays an important role in the digestion of different dietary components including fats and polysaccharides. Here we describe the contributing role of host genetics and the gut microbiome to dyslipidemia and discuss the potential therapeutic implications of advances in understanding the gut microbiome to the treatment of dyslipidemia.

Citing Articles

Chylomicron Characteristics Are Associated With Microsomal Triglyceride Transfer Protein in an Animal Model of Diet-Induced Dysbiosis.

Olano C, Farina G, Wiszniewski M, Medel J, Morales C, Friedman S J Lipid Atheroscler. 2025; 14(1):106-119.

PMID: 39911957 PMC: 11791422. DOI: 10.12997/jla.2025.14.1.106.

Altered gut microbiome and serum metabolome profiles associated with essential tremor.

Yan Z, Zheng Z, Cao L, Zhu Z, Zhou C, Sun Q Metab Brain Dis. 2025; 40(2):118.

PMID: 39903340 DOI: 10.1007/s11011-025-01549-2.

Interplays of Dietary Fat with BMI and rs324420 on HDL-C in Gender-Dependent Manner in Adolescents.

Shen Y, Qiu L, Cai J, Guo Q, Chen X, Su G Food Sci Nutr. 2024; 12(11):9287-9294.

PMID: 39619958 PMC: 11606812. DOI: 10.1002/fsn3.4497.

Primary Prevention Strategy for Non-Communicable Diseases (NCDs) and Their Risk Factors: The Role of Intestinal Microbiota.

Lopez-Tenorio I, Aguilar-Villegas O, Espinoza-Palacios Y, Segura-Real L, Pena-Aparicio B, Amedei A Biomedicines. 2024; 12(11).

PMID: 39595097 PMC: 11591598. DOI: 10.3390/biomedicines12112529.

Helicobacter pylori infection increases the risk of dyslipidemia in Chinese diabetic Population: a retrospective cross-sectional study.

Yang C, You N, Chen Y, Zhang J BMC Infect Dis. 2024; 24(1):730.

PMID: 39054452 PMC: 11270938. DOI: 10.1186/s12879-024-09597-2.

References

Wu G, Chen J, Hoffmann C, Bittinger K, Chen Y, Keilbaugh S . Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011; 334(6052):105-8. PMC: 3368382. DOI: 10.1126/science.1208344. View

Furusawa Y, Obata Y, Fukuda S, Endo T, Nakato G, Takahashi D . Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013; 504(7480):446-50. DOI: 10.1038/nature12721. View

Kathiresan S, Melander O, Guiducci C, Surti A, Burtt N, Rieder M . Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008; 40(2):189-97. PMC: 2682493. DOI: 10.1038/ng.75. View

Noriega B, Sanchez-Gonzalez M, Salyakina D, Coffman J . Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota. Case Rep Med. 2016; 2016:3089303. PMC: 4808672. DOI: 10.1155/2016/3089303. View

Canfora E, Jocken J, Blaak E . Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol. 2015; 11(10):577-91. DOI: 10.1038/nrendo.2015.128. View

Saxena R, Voight B, Lyssenko V, Burtt N, de Bakker P, Chen H . Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316(5829):1331-6. DOI: 10.1126/science.1142358. View

Kishino S, Takeuchi M, Park S, Hirata A, Kitamura N, Kunisawa J . Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013; 110(44):17808-13. PMC: 3816446. DOI: 10.1073/pnas.1312937110. View

Velasquez M, Ramezani A, Manal A, Raj D . Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel). 2016; 8(11). PMC: 5127123. DOI: 10.3390/toxins8110326. View

Cui C, Shen C, Jia G, Wang K . Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism. Genet Mol Res. 2013; 12(2):1766-76. DOI: 10.4238/2013.May.23.1. View

10.

Morais C, Oyama L, de Oliveira J, Garcia M, de Rosso V, Sousa Mendes Amigo L . Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring. Mediators Inflamm. 2014; 2014:987927. PMC: 4170783. DOI: 10.1155/2014/987927. View

11.

Vitek L, Haluzik M . The role of bile acids in metabolic regulation. J Endocrinol. 2016; 228(3):R85-96. DOI: 10.1530/JOE-15-0469. View

12.

Seidah N, Awan Z, Chretien M, Mbikay M . PCSK9: a key modulator of cardiovascular health. Circ Res. 2014; 114(6):1022-36. DOI: 10.1161/CIRCRESAHA.114.301621. View

13.

Backhed F, Ding H, Wang T, Hooper L, Koh G, Nagy A . The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44):15718-23. PMC: 524219. DOI: 10.1073/pnas.0407076101. View

14.

Buck G, Sever L, Batt R, Mendola P . Life-style factors and female infertility. Epidemiology. 1997; 8(4):435-41. DOI: 10.1097/00001648-199707000-00015. View

15.

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P . Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504(7480):451-5. PMC: 3869884. DOI: 10.1038/nature12726. View

16.

Batterham R, Cowley M, Small C, Herzog H, Cohen M, Dakin C . Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002; 418(6898):650-4. DOI: 10.1038/nature00887. View

17.

Kreznar J, Keller M, Traeger L, Rabaglia M, Schueler K, Stapleton D . Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Rep. 2017; 18(7):1739-1750. PMC: 5325228. DOI: 10.1016/j.celrep.2017.01.062. View

18.

Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G . TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009; 10(3):167-77. PMC: 2739652. DOI: 10.1016/j.cmet.2009.08.001. View

19.

An H, Park S, Lee D, Kim J, Cha M, Lee S . Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats. Lipids Health Dis. 2011; 10:116. PMC: 3146849. DOI: 10.1186/1476-511X-10-116. View

20.

Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G . Richness of human gut microbiome correlates with metabolic markers. Nature. 2013; 500(7464):541-6. DOI: 10.1038/nature12506. View