Experimental Models to Study Osteoarthritis Pain and Develop Therapeutics

Overview

Journal Osteoarthr Cartil Open

Date 2022 Dec 7

PMID 36474784

Authors

Kanyakorn Riewruja

Meagan Makarczyk

Peter G Alexander

Qi Gao

Stuart B Goodman

Bruce A Bunnell

Michael S Gold

Hang Lin

Affiliations

Soon will be listed here.

Abstract

Pain is the predominant symptom of osteoarthritis (OA) that drives patients to seek medical care. Currently, there are no pharmacological treatments that can reverse or halt the progression of OA. Safe and efficacious medications for long-term management of OA pain are also unavailable. Understanding the mechanisms behind OA pain generation at onset and over time is critical for developing effective treatments. In this narrative review, we first summarize our current knowledge on the innervation of the knee joint, and then discuss the molecular mechanism(s) currently thought to underlie OA pain. In particular, we focus on the contribution of each joint component to the generation of pain. Next, the current experimental models for studying OA pain are summarized, and the methods to assess pain in rodents are presented. The potential application of emerging microphysiological systems in OA pain research is especially highlighted. Lastly, we discuss the current challenge in standardizing models and the selection of appropriate systems to address specific questions.

Citing Articles

Cell Therapy Approaches for Articular Cartilage Regeneration.

Makarczyk M Organogenesis. 2023; 19(1):2278235.

PMID: 37963189 PMC: 10898818. DOI: 10.1080/15476278.2023.2278235.

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