Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries

Overview

Journal Stem Cells

Publisher Oxford University Press

Specialties Cell Biology
Reproductive Medicine

Date 2022 Dec 6

PMID 36472569

Authors

Dori C Woods

Jonathan L Tilly

Affiliations

Soon will be listed here.

Citing Articles

Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians.

Ogielska M, Chmielewska M, Rozenblut-Koscisty B Biology (Basel). 2025; 13(12.

PMID: 39765684 PMC: 11673927. DOI: 10.3390/biology13121017.

mTOR Inhibition via Low-Dose, Pulsed Rapamycin with Intraovarian Condensed Platelet Cytokines: An Individualized Protocol to Recover Diminished Reserve?.

Scott Sills E, Harrity C, Wood S, Tan S J Pers Med. 2023; 13(7).

PMID: 37511761 PMC: 10381109. DOI: 10.3390/jpm13071147.

Characterization of Oogonial Stem Cells in Adult Mouse Ovaries with Age and Comparison to In Silico Data on Human Ovarian Aging.

MacDonald J, Sheehan H, Piasecki A, Faustino L, Hauschildt C, Stolzenbach V Stem Cells Dev. 2023; 32(5-6):99-114.

PMID: 36594561 PMC: 9986025. DOI: 10.1089/scd.2022.0284.

In Reply: Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries.

Yoshihara M, Wagner M, Damdimopoulos A, Zhao C, Petropoulos S, Katayama S Stem Cells. 2022; 41(2):205-206.

PMID: 36472571 PMC: 9982065. DOI: 10.1093/stmcls/sxac084.

References

Ariyath A, Mangala Kanthi J, Paul-Prasanth B . Differentiation Potential of Cultured Extracellular DEAD-Box Helicase 4+ Oogonial Stem Cells from Adult Human Ovaries into Somatic Lineages. Cells Tissues Organs. 2021; 211(5):577-588. DOI: 10.1159/000519087. View

Zhang C, Wu J . Production of offspring from a germline stem cell line derived from prepubertal ovaries of germline reporter mice. Mol Hum Reprod. 2016; 22(7):457-64. DOI: 10.1093/molehr/gaw030. View

Bothun A, Gao Y, Takai Y, Ishihara O, Seki H, Karger B . Quantitative Proteomic Profiling of the Human Ovary from Early to Mid-Gestation Reveals Protein Expression Dynamics of Oogenesis and Folliculogenesis. Stem Cells Dev. 2018; 27(11):723-735. PMC: 5985909. DOI: 10.1089/scd.2018.0002. View

Sequeira R, Sittadjody S, Criswell T, Atala A, Jackson J, Yoo J . Enhanced method to select human oogonial stem cells for fertility research. Cell Tissue Res. 2021; 386(1):145-156. DOI: 10.1007/s00441-021-03464-1. View

Navaroli D, Tilly J, Woods D . Isolation of Mammalian Oogonial Stem Cells by Antibody-Based Fluorescence-Activated Cell Sorting. Methods Mol Biol. 2016; 1457:253-68. PMC: 8802829. DOI: 10.1007/978-1-4939-3795-0_19. View

Saber M, Tavakol P, Esfandiari F . Isolation of Female Germline Stem Cells from Mouse and Human Ovaries by Differential Adhesion. Int J Cell Biol. 2022; 2022:5224659. PMC: 9473869. DOI: 10.1155/2022/5224659. View

Silvestris E, Cafforio P, DOronzo S, Felici C, Silvestris F, Loverro G . In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization. Hum Reprod. 2018; 33(3):464-473. DOI: 10.1093/humrep/dex377. View

Wu M, Lu Z, Zhu Q, Ma L, Xue L, Li Y . DDX04+ Stem Cells in the Ovaries of Postmenopausal Women: Existence and Differentiation Potential. Stem Cells. 2022; 40(1):88-101. DOI: 10.1093/stmcls/sxab002. View

Johnson J, Skaznik-Wikiel M, Lee H, Niikura Y, Tilly J, Tilly J . Setting the record straight on data supporting postnatal oogenesis in female mammals. Cell Cycle. 2005; 4(11):1471-7. DOI: 10.4161/cc.4.11.2186. View

10.

Kanatsu-Shinohara M, Morimoto H, Shinohara T . Fertility of Male Germline Stem Cells Following Spermatogonial Transplantation in Infertile Mouse Models. Biol Reprod. 2016; 94(5):112. DOI: 10.1095/biolreprod.115.137869. View

11.

Hayashi K, Hikabe O, Obata Y, Hirao Y . Reconstitution of mouse oogenesis in a dish from pluripotent stem cells. Nat Protoc. 2017; 12(9):1733-1744. DOI: 10.1038/nprot.2017.070. View

12.

Zhang H, Liu L, Li X, Busayavalasa K, Shen Y, Hovatta O . Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice. Proc Natl Acad Sci U S A. 2014; 111(50):17983-8. PMC: 4273382. DOI: 10.1073/pnas.1421047111. View

13.

Johnson J, Canning J, Kaneko T, Pru J, Tilly J . Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004; 428(6979):145-50. DOI: 10.1038/nature02316. View

14.

White Y, Woods D, Takai Y, Ishihara O, Seki H, Tilly J . Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med. 2012; 18(3):413-21. PMC: 3296965. DOI: 10.1038/nm.2669. View

15.

Brinster R, Avarbock M . Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci U S A. 1994; 91(24):11303-7. PMC: 45219. DOI: 10.1073/pnas.91.24.11303. View

16.

Brinster R, Zimmermann J . Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci U S A. 1994; 91(24):11298-302. PMC: 45218. DOI: 10.1073/pnas.91.24.11298. View

17.

Woods D, White Y, Tilly J . Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future. Reprod Sci. 2012; 20(1):7-15. PMC: 3676240. DOI: 10.1177/1933719112462632. View

18.

Zhang Y, Yang Z, Yang Y, Wang S, Shi L, Xie W . Production of transgenic mice by random recombination of targeted genes in female germline stem cells. J Mol Cell Biol. 2010; 3(2):132-41. DOI: 10.1093/jmcb/mjq043. View

19.

Alberico H, Fleischmann Z, Bobbitt T, Takai Y, Ishihara O, Seki H . Workflow Optimization for Identification of Female Germline or Oogonial Stem Cells in Human Ovarian Cortex Using Single-Cell RNA Sequence Analysis. Stem Cells. 2022; 40(5):523-536. PMC: 9199849. DOI: 10.1093/stmcls/sxac015. View

20.

Oktay K, Baltaci V, Sonmezer M, Turan V, Unsal E, Baltaci A . Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation. Reprod Sci. 2015; 22(12):1612-7. DOI: 10.1177/1933719115612137. View