The RNA Editing Landscape in Acute Myeloid Leukemia Reveals Associations with Disease Mutations and Clinical Outcome

Overview

Journal iScience

Publisher Cell Press

Date 2022 Dec 5

PMID 36465109

Authors

Eshwar Meduri

Charles Breeze

Ludovica Marando

Simon e Richardson

Brian J P Huntly

Affiliations

Soon will be listed here.

Abstract

Several studies have documented aberrant RNA editing patterns across multiple tumors across large patient cohorts from The Cancer Genome Atlas (TCGA). However, studies on understanding the role of RNA editing in acute myeloid leukemia (AML) have been limited to smaller sample sizes. Using high throughput transcriptomic data from the TCGA, we demonstrated higher levels of editing as a predictor of poor outcome within the AML patient samples. Moreover, differential editing patterns were observed across individual AML genotypes. We also could demonstrate a negative association between the degree of editing and mRNA abundance for some transcripts, identifying the potential regulatory potential of RNA-editing in altering gene expression in AML. Further edQTL analysis suggests potential mechanisms in RNA editing variation. Our work suggests a functional and regulatory role of RNA editing in the pathogenesis of AML and we extended our analysis to gain insight into the factors influencing altered levels of editing.

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