Mass Cytometry Analysis of Blood from Peanut-sensitized Tolerant and Clinically Allergic Infants

Overview

Journal Sci Data

Specialty Science

Date 2022 Dec 1

PMID 36456584

Authors

Amanda R Tursi

Nicholas K Saba

Diane Dunham

Monali Manohar

Rachel L Peters

Richard Saffery

Jennifer J Koplin

Kari C Nadeau

Melanie R Neeland

Sandra Andorf

Affiliations

Soon will be listed here.

Abstract

IgE-mediated food allergies in infants are a significant health concern, with peanut allergy being of particular interest due to its prevalence and severity. Among individuals who produce peanut-specific IgE some experience no adverse reaction on peanut consumption. This asymptomatic phenotype is known as sensitized tolerance. To elucidate the immune environment of peanut sensitized tolerant and clinically allergic one-year-olds, high-dimensional mass cytometry was conducted as part of the HealthNuts study. The resulting data includes peripheral blood mononuclear cells from 36 participants encompassing non-allergic, peanut sensitized with tolerance, and clinically peanut allergic infants. The raw mass cytometry data is described here and freely available for reuse through the Immunology Database and Analysis Portal (ImmPort). Additional allergy information and serum vitamin D levels of the participants were measured and are also included in the data upload. These high-dimensional mass cytometry data, when combined with clinical information, offer a broad immune profile of peanut allergic and sensitized tolerant infants.

Citing Articles

Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants.

Tursi A, Saba N, Dunham D, Manohar M, Peters R, Saffery R Sci Data. 2022; 9(1):738.

PMID: 36456584 PMC: 9715645. DOI: 10.1038/s41597-022-01861-x.

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