Knowledge Atlas and Emerging Trends on NcRNAs of Osteosarcoma: A Bibliometric Analysis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Nov 28

PMID 36440224

Authors

Bo Wang

Chunhua Yang

Chuqiao Zhou

Shipeng Xiao

Hui Li

Affiliations

Soon will be listed here.

Abstract

Background: Osteosarcoma is a common bone sarcoma that occurs in childhood and adolescence. Although research on non-coding RNAs (ncRNAs) of osteosarcoma has been developed rapidly in recent years, a specific bibliometric analysis on this topic has not yet been performed. The bibliometric analysis aims to summarize knowledge atlas, research hotspots, and emerging trends and to provide researchers with new perspectives in further studies.

Methods: All publications regarding ncRNAs of osteosarcoma published from 2000 to 2021 were retrieved from the Web of Science Core Collection. Quantitative indicators including the number of publications and citations, H-index, and journal citation reports were analyzed by using Excel 2019 and R software. VOSviewer and CiteSpace were used to analyze the cooperation among countries/institutions/journals/authors and the co-occurrence of keywords, keywords bursts, and references.

Results: A total of 3206 publications were extracted. A significant growth trend in the annual number of publications over the past 22 years is revealed ( = 0.999). The most prolific country and institution were China (2260) and Shanghai Jiao Tong University (134), respectively. Professors Wang W and Liu W contributed the most to this field. The keywords were stratified into six clusters: Cluster 1 (apoptosis and growth), Cluster 2 (cancer and progression), Cluster 3 (microRNAs and downregulation), Cluster 4 (genes and differentiation), Cluster 5 (expression and biological functions), and Cluster 6 (metastasis). The long non-coding RNAs and circular RNAs have been considered as an important research hotspot in the near future.

Conclusion: This study offers a scientific perspective on ncRNAs of osteosarcoma and provides researchers with valuable information to understand the knowledge structure and to identify emerging trends in this field.

Citing Articles

A bibliometric worldview of breast-conserving surgery for breast cancer from 2013 to 2023.

Cao S, Wei Y, Huang J, Yue Y, Deng A, Zeng H Front Oncol. 2024; 14:1405351.

PMID: 39099692 PMC: 11294094. DOI: 10.3389/fonc.2024.1405351.

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study.

Cao S, Wei Y, Yue Y, Chen Y, Liao S, Li A Front Pharmacol. 2024; 15:1366852.

PMID: 38464725 PMC: 10921231. DOI: 10.3389/fphar.2024.1366852.

References

Silva G, Aboussekhra A . p16(INK4A) inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1. Mol Carcinog. 2015; 55(5):525-36. DOI: 10.1002/mc.22299. View

Li Z, Li X, Xu D, Chen X, Li S, Zhang L . An update on the roles of circular RNAs in osteosarcoma. Cell Prolif. 2020; 54(1):e12936. PMC: 7791175. DOI: 10.1111/cpr.12936. View

Jones K, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo G . miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res. 2012; 72(7):1865-77. PMC: 3328547. DOI: 10.1158/0008-5472.CAN-11-2663. View

Yang B, Li L, Tong G, Zeng Z, Tan J, Su Z . Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis. J Exp Clin Cancer Res. 2021; 40(1):235. PMC: 8283840. DOI: 10.1186/s13046-021-02027-0. View

Tan J, Zhou M, Yang S, Lin J . Long noncoding RNA HCP5 promotes osteosarcoma cell proliferation, invasion, and migration via the miR-29b-3p-LOXL2 axis. Kaohsiung J Med Sci. 2022; 38(10):960-970. DOI: 10.1002/kjm2.12577. View

Yang J, Rastetter R, Wilhelm D . Non-coding RNAs: An Introduction. Adv Exp Med Biol. 2015; 886:13-32. DOI: 10.1007/978-94-017-7417-8_2. View

Li S, Bai H, Chen X, Gong S, Xiao J, Li D . Soft Substrate Promotes Osteosarcoma Cell Self-Renewal, Differentiation, and Drug Resistance Through miR-29b and Its Target Protein Spin 1. ACS Biomater Sci Eng. 2020; 6(10):5588-5598. DOI: 10.1021/acsbiomaterials.0c00816. View

Leite T, Watters R, Weiss K, Intini G . Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma. J Transl Med. 2021; 19(1):450. PMC: 8555297. DOI: 10.1186/s12967-021-03122-8. View

Xiao-Long M, Kun-Peng Z, Chun-Lin Z . Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma. J Cancer. 2018; 9(10):1856-1862. PMC: 5968774. DOI: 10.7150/jca.24619. View

10.

Xu R, Feng F, Yu X, Liu Z, Lao L . LncRNA SNHG4 promotes tumour growth by sponging miR-224-3p and predicts poor survival and recurrence in human osteosarcoma. Cell Prolif. 2018; 51(6):e12515. PMC: 6528889. DOI: 10.1111/cpr.12515. View

11.

Yu X, Guo W, Zhang J, Ma C, Chu A, Wen B . Long non-codingRNA (lncRNA) TUG1 and the prognosis of cancer: a meta-analysis. Cell Mol Biol (Noisy-le-grand). 2017; 63(3):36-39. DOI: 10.14715/cmb/2017.63.3.7. View

12.

Wu W, Wang L, Li S . Hox transcript antisense RNA knockdown inhibits osteosarcoma progression by regulating the phosphoinositide 3-kinase/AKT pathway through the microRNA miR-6888-3p/spleen tyrosine kinase axis. Bioengineered. 2022; 13(4):9397-9410. PMC: 9161905. DOI: 10.1080/21655979.2022.2059614. View

13.

Zhu T, Fan D, Ye K, Liu B, Cui Z, Liu Z . Role of miRNA-542-5p in the tumorigenesis of osteosarcoma. FEBS Open Bio. 2020; 10(4):627-636. PMC: 7137799. DOI: 10.1002/2211-5463.12824. View

14.

Gomes A, Nolasco S, Soares H . Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci. 2013; 14(8):16010-39. PMC: 3759897. DOI: 10.3390/ijms140816010. View

15.

Zhang Y, Yang J, Zhao N, Wang C, Kamar S, Zhou Y . Progress in the chemotherapeutic treatment of osteosarcoma. Oncol Lett. 2018; 16(5):6228-6237. PMC: 6202490. DOI: 10.3892/ol.2018.9434. View

16.

Liu M, Yang P, Mao G, Deng J, Peng G, Ning X . Long non-coding RNA MALAT1 as a valuable biomarker for prognosis in osteosarcoma: A systematic review and meta-analysis. Int J Surg. 2019; 72:206-213. DOI: 10.1016/j.ijsu.2019.11.004. View

17.

Song B, Wang Y, Titmus M, Botchkina G, Formentini A, Kornmann M . Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. Mol Cancer. 2010; 9:96. PMC: 2881118. DOI: 10.1186/1476-4598-9-96. View

18.

Synnestvedt M, Chen C, Holmes J . CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2006; :724-8. PMC: 1560567. View

19.

Sheng G, Gao Y, Yang Y, Wu H . Osteosarcoma and Metastasis. Front Oncol. 2021; 11:780264. PMC: 8702962. DOI: 10.3389/fonc.2021.780264. View

20.

Wu H, Zhou Y, Xu L, Tong L, Wang Y, Liu B . Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study. Front Neurosci. 2021; 15:706105. PMC: 8316975. DOI: 10.3389/fnins.2021.706105. View