In Situ Synthesis of AZO-Np in Guar Gum/PVOH Composite Fiber Mats for Potential Bactericidal Release

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Nov 26

PMID 36433110

Authors

Adriana Freire Lubambo

Ney Mattoso

Lucy Ono

Gisele Gomes da Luz

Bruno Gavinho

Andressa Amado Martin

Maria Rita Sierakowski

Cyro Ketzer Saul

Affiliations

Soon will be listed here.

Abstract

Since the number of antibiotic-resistant bacterial infections is growing and cases are getting worse every year, the search for new alternative bactericidal wound dressing treatments is becoming crucial. Within this context, the use of polysaccharides from plants and seeds in innovative biopolymer technologies is of key importance. In this work, bio-nano-composite guar gum/polyvinyl alcohol (PVOH) membranes loaded with aluminum-doped zinc oxide nanoparticles were produced via electrospinning. Citric acid was added to the mixture to increase spinnability. However, depending on the pH, zinc oxide nanoparticles are partially dissociated, decreasing their bactericidal efficiency. Thus, a second successful alkaline thermo-chemical regrowth step was added to the process to treat the obtained fibers. This alkaline thermo-chemical treatment reconstituted both the nanoparticles and their bactericidal properties. The antibacterial assay results show that the membranes obtained after the alkaline thermo-chemical treatment presented a 57% increase in growth inhibition.

Citing Articles

Metal-Polymer Nanocomposites: A Promising Approach to Antibacterial Materials.

Ghazzy A, Naik R, Shakya A Polymers (Basel). 2023; 15(9).

PMID: 37177313 PMC: 10180664. DOI: 10.3390/polym15092167.

References

Sill T, von Recum H . Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008; 29(13):1989-2006. DOI: 10.1016/j.biomaterials.2008.01.011. View

Bhardwaj N, Kundu S . Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv. 2010; 28(3):325-47. DOI: 10.1016/j.biotechadv.2010.01.004. View

Lubambo A, Ono L, Drago V, Mattoso N, Varalda J, Sierakowski M . Tuning Fe3O4 nanoparticle dispersion through pH in PVA/guar gum/electrospun membranes. Carbohydr Polym. 2015; 134:775-83. DOI: 10.1016/j.carbpol.2015.08.013. View

Thomas L, Arun U, Remya S, Nair P . A biodegradable and biocompatible PVA-citric acid polyester with potential applications as matrix for vascular tissue engineering. J Mater Sci Mater Med. 2008; 20 Suppl 1:S259-69. DOI: 10.1007/s10856-008-3599-7. View

Anitha S, Brabu B, John Thiruvadigal D, Gopalakrishnan C, Natarajan T . Optical, bactericidal and water repellent properties of electrospun nano-composite membranes of cellulose acetate and ZnO. Carbohydr Polym. 2013; 97(2):856-63. DOI: 10.1016/j.carbpol.2013.05.003. View

Kanmani P, Rhim J . Properties and characterization of bionanocomposite films prepared with various biopolymers and ZnO nanoparticles. Carbohydr Polym. 2014; 106:190-9. DOI: 10.1016/j.carbpol.2014.02.007. View

Lubambo A, de Freitas R, Sierakowski M, Lucyszyn N, Sassaki G, Serafim B . Electrospinning of commercial guar-gum: Effects of purification and filtration. Carbohydr Polym. 2013; 93(2):484-91. DOI: 10.1016/j.carbpol.2013.01.031. View

Buonsanti R, LLordes A, Aloni S, Helms B, Milliron D . Tunable infrared absorption and visible transparency of colloidal aluminum-doped zinc oxide nanocrystals. Nano Lett. 2011; 11(11):4706-10. DOI: 10.1021/nl203030f. View

Seil J, Webster T . Antimicrobial applications of nanotechnology: methods and literature. Int J Nanomedicine. 2012; 7:2767-81. PMC: 3383293. DOI: 10.2147/IJN.S24805. View

10.

Corkhill P, Hamilton C, Tighe B . Synthetic hydrogels. VI. Hydrogel composites as wound dressings and implant materials. Biomaterials. 1989; 10(1):3-10. DOI: 10.1016/0142-9612(89)90002-1. View

11.

Hong Y, Li D, Zheng J, Zou G . In situ growth of ZnO nanocrystals from solid electrospun nanofiber matrixes. Langmuir. 2006; 22(17):7331-4. DOI: 10.1021/la0605992. View

12.

El-Fawal G . Preparation, characterization and antibacterial activity of biodegradable films prepared from carrageenan. J Food Sci Technol. 2014; 51(9):2234-9. PMC: 4152529. DOI: 10.1007/s13197-013-1255-9. View

13.

Shahid M, Bukhari S, Gul Y, Munir H, Anjum F, Zuber M . Graft polymerization of guar gum with acryl amide irradiated by microwaves for colonic drug delivery. Int J Biol Macromol. 2013; 62:172-9. DOI: 10.1016/j.ijbiomac.2013.08.018. View

14.

Kamoun E, Kenawy E, Chen X . A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res. 2017; 8(3):217-233. PMC: 5315442. DOI: 10.1016/j.jare.2017.01.005. View

15.

Bramhill J, Ross S, Ross G . Bioactive Nanocomposites for Tissue Repair and Regeneration: A Review. Int J Environ Res Public Health. 2017; 14(1). PMC: 5295317. DOI: 10.3390/ijerph14010066. View

16.

Li L, Deng J, Deng H, Liu Z, Xin L . Synthesis and characterization of chitosan/ZnO nanoparticle composite membranes. Carbohydr Res. 2010; 345(8):994-8. DOI: 10.1016/j.carres.2010.03.019. View

17.

Kaith B, Sharma R, Kalia S . Guar gum based biodegradable, antibacterial and electrically conductive hydrogels. Int J Biol Macromol. 2015; 75:266-75. DOI: 10.1016/j.ijbiomac.2015.01.046. View

18.

Garg K, Bowlin G . Electrospinning jets and nanofibrous structures. Biomicrofluidics. 2011; 5(1):13403. PMC: 3082340. DOI: 10.1063/1.3567097. View

19.

Thombare N, Jha U, Mishra S, Siddiqui M . Guar gum as a promising starting material for diverse applications: A review. Int J Biol Macromol. 2016; 88:361-72. DOI: 10.1016/j.ijbiomac.2016.04.001. View

20.

Wang H, Wick R, Xing B . Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. Environ Pollut. 2008; 157(4):1171-7. DOI: 10.1016/j.envpol.2008.11.004. View