Transcriptome Analysis Reveals Genes Contributed to Min Pig Villi Hair Follicle in Different Seasons

Overview

Journal Vet Sci

Publisher MDPI

Specialty Veterinary Medicine

Date 2022 Nov 24

PMID 36423088

Authors

Ming Tian

Xinmiao He

WenTao Wang

Yanzhong Feng

Dongjie Zhang

Zhongqiu Li

Di Liu

Affiliations

Soon will be listed here.

Abstract

The Min pig, a local pig breed in China, has a special trait which has intermittent villus and coat hair regeneration. However, the regulation and mechanism of villus in Min pigs have not yet been described. We observed and described the phenotype of Min pig dermal villi in detail and sequenced the mRNA transcriptome of Min pig hair follicles. A total of 1520 differentially expressed genes (DEG) were obtained.K-means hierarchical clustering showed that there was a significant expression pattern difference in winter compared with summer. Gene enrichment and network analysis results showed that the hair growth in Min pigs was closely related to the composition of desmosomes and regulated by an interaction network composed of eight core genes, namely , , , , , , , and . Methylation analysis of promoters of target genes showed that the gene was demethylated. Our study will help to supplement current knowledge of the growth mechanism of different types of hair.

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