Research Status and Application Prospects of the Medicinal Mushroom Armillaria Mellea

Overview

Journal Appl Biochem Biotechnol

Specialties Biochemistry
Biotechnology

Date 2022 Nov 23

PMID 36417110

Authors

Sizhu Ren

Yiping Gao

Hui Li

Honghong Ma

Xiaoling Han

Zitong Yang

Wenjie Chen

Affiliations

Soon will be listed here.

Abstract

Armillaria is one of the most common diseases underlying chronic root rot in woody plants. Although there is no particularly effective way to prevent it, soil disinfection is a common effective protective measure. However, Armillaria itself has important medicinal value and is a symbiotic fungus in the cultivation of Gastrodia elata and Polyporus umbellatus. Therefore, researching Armillaria is of great practical significance. In this review, the biological characteristics, cultivation methods, chemical components, food and medicinal value and efficacy of Armillaria were all reviewed, and its development and utilization direction were analyzed and discussed.

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References

Zhang T, Du Y, Liu X, Sun X, Cai E, Zhu H . Study on antidepressant-like effect of protoilludane sesquiterpenoid aromatic esters from . Nat Prod Res. 2019; 35(6):1042-1045. DOI: 10.1080/14786419.2019.1614577. View

Heinzelmann R, Prospero S, Rigling D . Frequent diploidisation of haploid Armillaria ostoyae strains in an outdoor inoculation experiment. Fungal Biol. 2018; 122(2-3):147-155. DOI: 10.1016/j.funbio.2017.12.005. View

Bloomfield B, Alexander M . Melanins and resistance of fungi to lysis. J Bacteriol. 1967; 93(4):1276-80. PMC: 276597. DOI: 10.1128/jb.93.4.1276-1280.1967. View

Coetzee M, Bloomer P, Wingfield M, Wingfield B . Paleogene radiation of a plant pathogenic mushroom. PLoS One. 2012; 6(12):e28545. PMC: 3247210. DOI: 10.1371/journal.pone.0028545. View

Coetzee M, Wingfield B, Wingfield M . Armillaria Root-Rot Pathogens: Species Boundaries and Global Distribution. Pathogens. 2018; 7(4). PMC: 6313743. DOI: 10.3390/pathogens7040083. View

Wang Y, Zhang Y, Zheng L, Bao Y, Wu Y, Yu C . A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration. J Asian Nat Prod Res. 2013; 15(2):203-8. DOI: 10.1080/10286020.2012.751977. View

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O . Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2. Am J Chin Med. 2018; 46(3):585-599. DOI: 10.1142/S0192415X18500301. View

Giardina P, Faraco V, Pezzella C, Piscitelli A, Vanhulle S, Sannia G . Laccases: a never-ending story. Cell Mol Life Sci. 2009; 67(3):369-85. PMC: 11115910. DOI: 10.1007/s00018-009-0169-1. View

Herath H, Jacob M, Wilson A, Abbas H, Nanayakkara N . New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens. Nat Prod Res. 2012; 27(17):1562-8. PMC: 3595380. DOI: 10.1080/14786419.2012.738206. View

10.

Heinzelmann R, Croll D, Zoller S, Sipos G, Munsterkotter M, Guldener U . High-density genetic mapping identifies the genetic basis of a natural colony morphology mutant in the root rot pathogen Armillaria ostoyae. Fungal Genet Biol. 2017; 108:44-54. DOI: 10.1016/j.fgb.2017.08.007. View

11.

Lung M, Huang P . Optimization of exopolysaccharide production from Armillaria mellea in submerged cultures. Lett Appl Microbiol. 2009; 50(2):198-204. DOI: 10.1111/j.1472-765X.2009.02777.x. View

12.

Miguelez E, Martin C, Hardisson C, Manzanal M . Synchronous germination of Streptomyces antibioticus spores: tool for the analysis of hyphal growth in liquid cultures. FEMS Microbiol Lett. 1993; 109(2-3):123-9. DOI: 10.1111/j.1574-6968.1993.tb06156.x. View

13.

Shi X, Monaco M, Donovan S, Lee Y . Encapsulation of tributyrin by gamma-cyclodextrin: Complexation, spray drying, and in vitro fermentation. J Food Sci. 2020; 85(10):2986-2993. DOI: 10.1111/1750-3841.15440. View

14.

Carnevali P, Ciati R, Leporati A, Paese M . Liquid sourdough fermentation: industrial application perspectives. Food Microbiol. 2006; 24(2):150-4. DOI: 10.1016/j.fm.2006.07.009. View

15.

Sahu N, Merenyi Z, Balint B, Kiss B, Sipos G, Owens R . Hallmarks of Basidiomycete Soft- and White-Rot in Wood-Decay -Omics Data of Two Species. Microorganisms. 2021; 9(1). PMC: 7827401. DOI: 10.3390/microorganisms9010149. View

16.

Porter D, Bradshaw A, Nielsen R, Newell P, Dentinger B, Naleway S . The melanized layer of Armillaria ostoyae rhizomorphs: Its protective role and functions. J Mech Behav Biomed Mater. 2021; 125:104934. DOI: 10.1016/j.jmbbm.2021.104934. View

17.

Makinen M, Risulainen N, Mattila H, Lundell T . Transcription of lignocellulose-decomposition associated genes, enzyme activities and production of ethanol upon bioconversion of waste substrate by Phlebia radiata. Appl Microbiol Biotechnol. 2018; 102(13):5657-5672. DOI: 10.1007/s00253-018-9045-y. View

18.

Fradj N, de Montigny N, Merindol N, Awwad F, Boumghar Y, Germain H . A First Insight into North American Plant Pathogenic Fungi Transcriptome. Biology (Basel). 2020; 9(7). PMC: 7407180. DOI: 10.3390/biology9070153. View

19.

Heinzelmann R, Prospero S, Rigling D . Virulence and Stump Colonization Ability of Armillaria borealis on Norway Spruce Seedlings in Comparison to Sympatric Armillaria Species. Plant Dis. 2019; 101(3):470-479. DOI: 10.1094/PDIS-06-16-0933-RE. View

20.

Miller S, Gasic K, Reighard G, Henderson W, Rollins P, Vassalos M . Preventative Root-Collar Excavation Reduces Peach Tree Mortality Caused By Armillaria Root Rot On Replant Sites. Plant Dis. 2020; 104(5):1274-1279. DOI: 10.1094/PDIS-09-19-1831-RE. View