Laccases: a Never-ending Story

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2009 Oct 22

PMID 19844659

Citations 241

Authors

Paola Giardina

Vincenza Faraco

Cinzia Pezzella

Alessandra Piscitelli

Sophie Vanhulle

Giovanni Sannia

Affiliations

Soon will be listed here.

Abstract

Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure-function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.

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