Thermodynamic Analysis of the Interactions Between Human ACE2 and Spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)

Overview

Journal FEBS Open Bio

Specialty Biology

Date 2022 Nov 23

PMID 36416453

Authors

Agnieszka Rombel-Bryzek

Adriana Miller

Danuta Witkowska

Affiliations

Soon will be listed here.

Abstract

There are many scientific reports on the interaction of the SARS-CoV-2 virus S protein (and its RBD) with the human ACE2 receptor protein. However, there are no reliable data on how this interaction differs from the interaction of the receptor binding domain of SARS-CoV-1 with ACE2, in terms of binding strength and changes in reaction enthalpy and entropy. Our studies have revealed these differences and the impact of zinc ions on this interaction. Intriguingly, the binding affinity of both RBDs (of SARS-CoV-1 and of SARS-CoV-2) to the ACE2 receptor protein is almost identical; however, there are some differences in the entropic and enthalpic contributions to these interactions.

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