Effects of Collagen Peptides from Skin on Oxidative Damage Induced by Cyclophosphamide in Mice

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Nov 21

PMID 36407538

Authors

Mengyao Han

Zhongshan Zhang

Xinyue Li

Haibin Tong

Zhiguo Xu

Zikang Ding

Anquan Yang

Min Xie

Xiaomei Wang

Affiliations

Soon will be listed here.

Abstract

To investigate the protective effect of collagen peptide from skin (CPMs) on oxidative damage induced by cyclophosphamide in mice. Balb/c female mice were divided into blank, model (cyclophosphamide, CTX), positive control (levamisole hydrochloride), and collagen peptide low-, medium-, and high-dose groups. The results showed that CPMs increase the body mass and immune-related organ indexes, such as liver and kidneys of immunosuppressed mice. The activities of ALT, AST, UA, BUN, and MDA in the liver and kidney tissues decreased significantly, while those of SOD and GSH-Px increased significantly. CPMs can relieve the pathological damage to immune organs. CPMs significantly increase the activities of IL-2, IgG, and TNF-α in serum and SOD activity, while the MDA content was decreased compared to the model group. CPMs can exert a protective effect on cyclophosphamide-induced oxidative damage and have application prospects in the field of health food.

Citing Articles

Modulation of cyclophosphamide-induced immunosuppression and intestinal flora in broiler by deep eutectic solvent extracted polysaccharides of .

Su J, Xue J, Wang X, Zhang R, Zhang X, Yang Y Front Vet Sci. 2024; 11:1415716.

PMID: 38863455 PMC: 11165361. DOI: 10.3389/fvets.2024.1415716.

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