Sister Mary Joseph's Nodule From Renal Cell Carcinoma: A Case Report

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Nov 21

PMID 36407130

Authors

Kimiko Hirata

Masaru Narabayashi

Takaya Murashima

Takehiko Segawa

Shuji Ohtsu

Affiliations

Soon will be listed here.

Abstract

Sister Mary Joseph's nodules (SMJNs) are umbilical skin metastases of various abdominopelvic malignancies, and they rarely originate from renal cell carcinomas. Radiotherapy is typically used to treat the nodules as a palliative intention. We report a rare case of SMJN that originated from clear cell renal cell carcinoma, which was treated with external beam radiation therapy (EBRT) and interstitial brachytherapy (ISBT). A 74-year-old male patient with a history of left renal cell carcinoma developed an umbilical nodule which was diagnosed as SMJN. The patient underwent EBRT (30 Gy in 10 fractions) and ISBT (12 Gy in two fractions), leading the nodule to complete resolution. This case report might support that radiotherapy, including ISBT, is effective for the treatment of SMJN from renal cell carcinoma.

Citing Articles

Radiation Therapy for Sister Mary Joseph's Nodule: A Review.

Sasai K, Kawamura M, Okumura K, Kawai Y Adv Radiat Oncol. 2024; 9(2):101321.

PMID: 38405321 PMC: 10885576. DOI: 10.1016/j.adro.2023.101321.

References

Chalya P, Mabula J, Rambau P, Mchembe M . Sister Mary Joseph's nodule at a University teaching hospital in northwestern Tanzania: a retrospective review of 34 cases. World J Surg Oncol. 2013; 11:151. PMC: 3710260. DOI: 10.1186/1477-7819-11-151. View

De Meerleer G, Khoo V, Escudier B, Joniau S, Bossi A, Ost P . Radiotherapy for renal-cell carcinoma. Lancet Oncol. 2014; 15(4):e170-7. DOI: 10.1016/S1470-2045(13)70569-2. View

Hugen N, Kanne H, Simmer F, van de Water C, Voorham Q, Ho V . Umbilical metastases: Real-world data shows abysmal outcome. Int J Cancer. 2021; 149(6):1266-1273. PMC: 8361932. DOI: 10.1002/ijc.33684. View

Dar I, Kamili M, Dar S, Kuchaai F . Sister Mary Joseph nodule-A case report with review of literature. J Res Med Sci. 2011; 14(6):385-7. PMC: 3129082. View

Ishibashi N, Maebayashi T, Hata M, Okada M . The role of palliative radiation therapy in treating pleural or peritoneal disseminated tumors: 22 cases and a review of the literature. Ann Palliat Med. 2020; 9(5):2586-2591. DOI: 10.21037/apm-19-495. View

Iavazzo C, Madhuri K, Essapen S, Akrivos N, Tailor A, Butler-Manuel S . Sister Mary Joseph's Nodule as a First Manifestation of Primary Peritoneal Cancer. Case Rep Obstet Gynecol. 2012; 2012:467240. PMC: 3485758. DOI: 10.1155/2012/467240. View

Zelefsky M, Greco C, Motzer R, Magsanoc J, Pei X, Lovelock M . Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys. 2011; 82(5):1744-8. PMC: 4034682. DOI: 10.1016/j.ijrobp.2011.02.040. View

Appalanaido G, Shukor S, Fan A, Chong S, Hussin H, Karim N . Palliative brachytherapy to axilla and hypopharynx in elderly patient with hypopharyngeal squamous cell carcinoma - case report. Rep Pract Oncol Radiother. 2021; 26(4):647-653. PMC: 8382068. DOI: 10.5603/RPOR.a2021.0076. View

Homs M, Steyerberg E, Eijkenboom W, Tilanus H, Stalpers L, Bartelsman J . Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial. Lancet. 2004; 364(9444):1497-504. DOI: 10.1016/S0140-6736(04)17272-3. View

10.

Siva S, Bressel M, Wood S, Shaw M, Loi S, Sandhu S . Stereotactic Radiotherapy and Short-course Pembrolizumab for Oligometastatic Renal Cell Carcinoma-The RAPPORT Trial. Eur Urol. 2021; 81(4):364-372. DOI: 10.1016/j.eururo.2021.12.006. View

11.

Gabriele R, Conte M, Egidi F, Borghese M . Umbilical metastases: current viewpoint. World J Surg Oncol. 2005; 3(1):13. PMC: 552325. DOI: 10.1186/1477-7819-3-13. View

12.

Chen P, Middlebrook M, Goldman S, Sandler C . Sister Mary Joseph nodule from metastatic renal cell carcinoma. J Comput Assist Tomogr. 1998; 22(5):756-7. DOI: 10.1097/00004728-199809000-00017. View

13.

Escudier B, Porta C, Schmidinger M, Rioux-Leclercq N, Bex A, Khoo V . Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 2019; 30(5):706-720. DOI: 10.1093/annonc/mdz056. View