The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

Overview

Journal Emerg Med Int

Publisher Wiley

Specialty Emergency Medicine

Date 2022 Nov 21

PMID 36406930

Authors

Maosheng Lin

Louwei Zhang

Xuhua Tang

Yejiang Tang

Affiliations

Soon will be listed here.

Abstract

Sepsis is a dysfunction of various organs caused by a dysfunctional host response induced by infection. In recent years, the mortality rate of sepsis patients, especially the mortality rate of septic shock patients still remains high. Due to the complexity and heterogeneity of sepsis, there is currently a lack of clinical biomarkers that can be widely used for the early assessment of sepsis. In order to find more concise and accurate biomarkers for timely and adequate intervention in sepsis, we explored the value of neutrophil/lymphocyte ratio (NLR) combined with red blood cell distribution width (RDW) in assessing the prognosis of emergency sepsis patients. The results showed that NLR and RDW were closely related to the prognosis of emergency sepsis patients. The combination of the two can evaluate the prognosis of patients with emergency sepsis, which deserves close attention from clinicians.

Citing Articles

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.

Sacchetti S, Vidali M, Esposito T, Zorzi S, Burgener A, Ciccarello L Diagnostics (Basel). 2024; 14(3).

PMID: 38337856 PMC: 10855753. DOI: 10.3390/diagnostics14030340.

[Research advances of sepsis biomarkers].

Zeng Z, Peng Y, Yuan Z Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023; 39(7):679-684.

PMID: 37805698 PMC: 11630190. DOI: 10.3760/cma.j.cn501225-20230320-00086.

References

de Souza D, Martin J, Lanziotti V, Flauzino de Oliveira C, Tonial C, Brunow de Carvalho W . The epidemiology of sepsis in paediatric intensive care units in Brazil (the Sepsis PREvalence Assessment Database in Pediatric population, SPREAD PED): an observational study. Lancet Child Adolesc Health. 2021; 5(12):873-881. DOI: 10.1016/S2352-4642(21)00286-8. View

Umemura Y, Ogura H, Takuma K, Fujishima S, Abe T, Kushimoto S . Current spectrum of causative pathogens in sepsis: A prospective nationwide cohort study in Japan. Int J Infect Dis. 2020; 103:343-351. DOI: 10.1016/j.ijid.2020.11.168. View

Chen F, Kung C, Cheng H, Cheng C, Tsai T, Hsiao S . Quick Sepsis-related Organ Failure Assessment predicts 72-h mortality in patients with suspected infection. Eur J Emerg Med. 2018; 26(5):323-328. PMC: 6727935. DOI: 10.1097/MEJ.0000000000000563. View

Pantzaris N, Platanaki C, Pierrako C, Karamouzos V, Velissaris D . Neutrophil-to-lymphocyte Ratio Relation to Sepsis Severity Scores and Inflammatory Biomarkers in Patients with Community-acquired Pneumonia: A Case Series. J Transl Int Med. 2018; 6(1):43-46. PMC: 5874487. DOI: 10.2478/jtim-2018-0009. View

Brooks D, Polubothu P, Young D, Booth M, Smith A . Sepsis caused by bloodstream infection in patients in the intensive care unit: the impact of inactive empiric antimicrobial therapy on outcome. J Hosp Infect. 2017; 98(4):369-374. DOI: 10.1016/j.jhin.2017.09.031. View

Khosrojerdi A, Soudi S, Zavaran Hosseini A, Eshghi F, Shafiee A, Hashemi S . Immunomodulatory and Therapeutic Effects of Mesenchymal Stem Cells on Organ Dysfunction in Sepsis. Shock. 2020; 55(4):423-440. DOI: 10.1097/SHK.0000000000001644. View

Olejarova M, Dobisova A, Suchankova M, Tibenska E, Szaboova K, Koutun J . Vitamin D deficiency - a potential risk factor for sepsis development, correlation with inflammatory markers, SOFA score and higher early mortality risk in sepsis. Bratisl Lek Listy. 2019; 120(4):284-290. DOI: 10.4149/BLL_2019_040. View

Madushani R, Patel V, Loftus T, Ren Y, Li H, Velez L . Early Biomarker Signatures in Surgical Sepsis. J Surg Res. 2022; 277:372-383. PMC: 9827429. DOI: 10.1016/j.jss.2022.04.052. View

Hammond N, Kumar A, Kaur P, Vijayaraghavan B, Ghosh A, Grattan S . Estimates of Sepsis Prevalence and Outcomes in Adult Patients in the ICU in India: A Cross-sectional Study. Chest. 2022; 161(6):1543-1554. DOI: 10.1016/j.chest.2021.12.673. View

10.

Shankar-Hari M, Phillips G, Levy M, Seymour C, Liu V, Deutschman C . Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8):775-87. PMC: 4910392. DOI: 10.1001/jama.2016.0289. View

11.

Akinosoglou K, Kapsokosta G, Mouktaroudi M, Rovina N, Kaldis V, Stefos A . Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature. J Diabetes Complications. 2020; 35(1):107765. DOI: 10.1016/j.jdiacomp.2020.107765. View

12.

van den Berg M, van Beuningen F, Ter Maaten J, Bouma H . Hospital-related costs of sepsis around the world: A systematic review exploring the economic burden of sepsis. J Crit Care. 2022; 71:154096. DOI: 10.1016/j.jcrc.2022.154096. View

13.

Simpson G, Saunders R, Wilson J, Magee C . The role of the neutrophil:lymphocyte ratio (NLR) and the CRP:albumin ratio (CAR) in predicting mortality following emergency laparotomy in the over 80 age group. Eur J Trauma Emerg Surg. 2017; 44(6):877-882. DOI: 10.1007/s00068-017-0869-4. View

14.

Arvaniti K, Dimopoulos G, Antonelli M, Blot K, Creagh-Brown B, Deschepper M . Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study. Int J Antimicrob Agents. 2022; 60(1):106591. DOI: 10.1016/j.ijantimicag.2022.106591. View

15.

Meyer N, Harhay M, Small D, Prescott H, Bowles K, Gaieski D . Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis. Crit Care Med. 2018; 46(3):354-360. PMC: 5896750. DOI: 10.1097/CCM.0000000000002872. View

16.

Kim J, Kim K, Lee H, Ahn S . Epidemiology of sepsis in Korea: a population-based study of incidence, mortality, cost and risk factors for death in sepsis. Clin Exp Emerg Med. 2019; 6(1):49-63. PMC: 6453691. DOI: 10.15441/ceem.18.007. View

17.

Kopczynska M, Sharif B, Cleaver S, Spencer N, Kurani A, Lee C . Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward. Medicine (Baltimore). 2018; 97(49):e13238. PMC: 6310498. DOI: 10.1097/MD.0000000000013238. View

18.

Huang C, Ruan S, Tsai Y, Ku S, Yu C . Clinical Trajectories and Causes of Death in Septic Patients with a Low APACHE II Score. J Clin Med. 2019; 8(7). PMC: 6678558. DOI: 10.3390/jcm8071064. View

19.

Sano H, Kobayashi R, Iguchi A, Suzuki D, Kishimoto K, Yasuda K . Risk factors for sepsis-related death in children and adolescents with hematologic and malignant diseases. J Microbiol Immunol Infect. 2015; 50(2):232-238. DOI: 10.1016/j.jmii.2015.04.002. View

20.

Brakenridge S, Efron P, Cox M, Stortz J, Hawkins R, Ghita G . Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes. Ann Surg. 2019; 270(3):502-510. PMC: 6942687. DOI: 10.1097/SLA.0000000000003458. View