Telomeres Expand Sphere of Influence: Emerging Molecular Impact of Telomeres in Non-telomeric Functions

Overview

Journal Trends Genet

Specialty Genetics

Date 2022 Nov 20

PMID 36404192

Authors

Soujanya Vinayagamurthy

Sulochana Bagri

Jean-Louis Mergny

Shantanu Chowdhury

Affiliations

Soon will be listed here.

Abstract

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome - through factors that associate at telomeres and genome wide - and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.

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