Transplantable Human Thyroid Organoids Generated from Embryonic Stem Cells to Rescue Hypothyroidism

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Nov 17

PMID 36396935

Authors

Mirian Romitti

Adrien Tourneur

Barbara de Faria da Fonseca

Gilles Doumont

Pierre Gillotay

Xiao-Hui Liao

Sema Elif Eski

Gaetan Van Simaeys

Laura Chomette

Helene Lasolle

Olivier Monestier

Dominika Figini Kasprzyk

Vincent Detours

Sumeet Pal Singh

Serge Goldman

Samuel Refetoff

Sabine Costagliola

Affiliations

Soon will be listed here.

Abstract

The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development.

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