[ F]PSMA-1007 Renal Uptake Parameters: Reproducibility and Relationship to Estimated Glomerular Filtration Rate

Overview

Journal Clin Physiol Funct Imaging

Specialties Pathology
Physiology
Radiology

Date 2022 Nov 17

PMID 36385577

Authors

Kristian Valind

Jonas Jogi

David Minarik

Elin Tragardh

Affiliations

Soon will be listed here.

Abstract

Background: Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([ Tc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [ Tc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [ Ga]Ga-PSMA-11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [ F]PSMA-1007 uptake and eGFR.

Methods: Hundred and eighty-five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [ F]PSMA-1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUV ) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable.

Results: Variation in the eGFR values was explained to a significant degree by SUV and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD-EPI eGFR (1 h R = 0.64; 2 h R = 0.64) than for MDRD eGFR (1 h R = 0.47; 2 h R = 0.45).

Conclusion: Renal [ F]PSMA-1007 uptake parameters correlate with eGFR and are indicative of renal cortical function.

Citing Articles

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A Comparison of Ga-PSMA PET/CT-Based Split Renal Function with Tc-MAG3 Renography in Patients with Metastatic Castration-Resistant Prostate Carcinoma Treated with Lu-PSMA.

Gabela L, Mkhize T, Hadebe B, Harry L, Nxasana T, Ndlovu N Diagnostics (Basel). 2024; 14(6).

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[F]PSMA-1007 PET is comparable to [Tc]Tc-DMSA SPECT for renal cortical imaging.

Valind K, Minarik D, Garpered S, Persson E, Jogi J, Tragardh E Eur J Hybrid Imaging. 2023; 7(1):25.

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An exploratory study of unexplained concentration of F-PSMA-1007 in the bladder for prostate cancer PET/CT imaging.

Dang J, Yao Y, Li Y, Tan X, Ye Z, Zhao Y Front Med (Lausanne). 2023; 10:1238333.

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Erratum.

Clin Physiol Funct Imaging. 2023; 43(6):472-474.

PMID: 37395515 PMC: 11061867. DOI: 10.1111/cpf.12844.

References

Hofman M, Lawrentschuk N, Francis R, Tang C, Vela I, Thomas P . Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study. Lancet. 2020; 395(10231):1208-1216. DOI: 10.1016/S0140-6736(20)30314-7. View

Yee C, Lee H, BLAUFOX M . Tc-99m DMSA renal uptake: influence of biochemical and physiologic factors. J Nucl Med. 1981; 22(12):1054-8. View

Dissing T, Eskild-Jensen A, Pedersen M, Anderson P, Rittig N, Frokiaer J . Reproducibility and repeatability of differential renal function in 4-week-old piglets. Nucl Med Commun. 2007; 29(1):76-82. DOI: 10.1097/MNM.0b013e3282f20e1f. View

Valind K, Jogi J, Minarik D, Brolin G, Tragardh E . Dose-reduced [F]PSMA-1007 PET is feasible for functional imaging of the renal cortex. EJNMMI Phys. 2021; 8(1):70. PMC: 8556440. DOI: 10.1186/s40658-021-00419-x. View

Sarikaya I, Elgazzar A, Alfeeli M, Sarikaya A . Can Gallium-68 Prostate-specific Membrane Antigen Ligand be a Potential Radiotracer for Renal Cortical Positron Emission Tomography Imaging?. World J Nucl Med. 2018; 17(2):126-129. PMC: 5905259. DOI: 10.4103/wjnm.WJNM_35_17. View

Inker L, Eneanya N, Coresh J, Tighiouart H, Wang D, Sang Y . New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021; 385(19):1737-1749. PMC: 8822996. DOI: 10.1056/NEJMoa2102953. View

Tondeur M, Melis K, De Sadeleer C, Verelst J, Van Espen M, Ham H . Inter-observer reproducibility of relative 99Tcm-DMSA uptake. Nucl Med Commun. 2000; 21(5):449-53. DOI: 10.1097/00006231-200005000-00007. View

Valind K, Jogi J, Minarik D, Tragardh E . [ F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate. Clin Physiol Funct Imaging. 2022; 43(2):128-135. PMC: 10100348. DOI: 10.1111/cpf.12801. View

Taylor Jr A, Kipper M, Witztum K . Calculation of relative glomerular filtration rate and correlation with delayed technetium-99m DMSA imaging. Clin Nucl Med. 1986; 11(1):28-31. DOI: 10.1097/00003072-198601000-00010. View

10.

Sarikaya I, AlQallaf A, Sarikaya A, Baqer A, Kazem N . Renal Cortical Scarring: Ga-PSMA-11 PET Versus Tc-DMSA Scanning in a Case of Pyelonephritis. J Nucl Med Technol. 2021; 50(1):49-53. DOI: 10.2967/jnmt.121.262415. View

11.

Groshar D, Embon O, Frenkel A, Front D . Renal function and technetium-99m-dimercaptosuccinic acid uptake in single kidneys: the value of in vivo SPECT quantitation. J Nucl Med. 1991; 32(5):766-8. View

12.

Piepsz A, BLAUFOX M, Gordon I, Granerus G, Majd M, OReilly P . Consensus on renal cortical scintigraphy in children with urinary tract infection. Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med. 1999; 29(2):160-74. DOI: 10.1016/s0001-2998(99)80006-3. View

13.

Kinoshita Y, Kuratsukuri K, Landas S, Imaida K, Rovito Jr P, Wang C . Expression of prostate-specific membrane antigen in normal and malignant human tissues. World J Surg. 2006; 30(4):628-36. DOI: 10.1007/s00268-005-0544-5. View

14.

Kawamura J, Hosokawa S, Yoshida O, Fujita T, Ishii Y, Torizuka K . Validity of 99mTc dimercaptosuccinic acid renal uptake for an assessment for individual kidney function. J Urol. 1978; 119(3):305-9. DOI: 10.1016/s0022-5347(17)57471-6. View

15.

WILLIS K, Martinez D, Hedley-Whyte E, Davis M, Judy P, Treves S . Renal localization of 99mTc-stannous glucophetonate and 99mTc-stannous dimercaptosuccinate in the rat by frozen section autoradiography. The efficiency and resolution of technetium-99m. Radiat Res. 1977; 69(3):475-88. View

16.

Goodgold H, Fletcher J, Steinhardt G . Quantitative technetium-99M dimercaptosuccinic acid renal scanning in children. Urology. 1996; 47(3):405-8. DOI: 10.1016/s0090-4295(99)80461-0. View

17.

Stevens L, Schmid C, Zhang Y, Coresh J, Manzi J, Landis R . Development and validation of GFR-estimating equations using diabetes, transplant and weight. Nephrol Dial Transplant. 2009; 25(2):449-57. PMC: 2910328. DOI: 10.1093/ndt/gfp510. View

18.

Levey A, Coresh J, Greene T, Stevens L, Zhang Y, Hendriksen S . Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006; 145(4):247-54. DOI: 10.7326/0003-4819-145-4-200608150-00004. View

19.

Schierz J, Sarikaya I, Albatineh A, Sarikaya A . Assessing the Correlation Between Ga-PSMA-11 Renal PET Parameters and Renal Function Tests. J Nucl Med Technol. 2021; 50(1):43-48. DOI: 10.2967/jnmt.121.262462. View

20.

Conen P, Pennetta F, Dendl K, Hertel F, Vogg A, Haberkorn U . [ Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease. Eur J Nucl Med Mol Imaging. 2022; 49(10):3365-3372. PMC: 9308582. DOI: 10.1007/s00259-021-05660-1. View