Ferroptosis-based Nano Delivery Systems Targeted Therapy for Colorectal Cancer: Insights and Future Perspectives

Overview

Journal Asian J Pharm Sci

Date 2022 Nov 16

PMID 36382305

Authors

Chu Qiao

Haiying Wang

Qiutong Guan

Minjie Wei

Zhenhua Li

Affiliations

Soon will be listed here.

Abstract

There are limited options for patients who develop liver metastasis from colorectal cancer (CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has provided insights into iron deficiency and excess in CRC. Ferroptosis is an iron-dependent form of programmed cell death characterized by aberrant iron and lipid metabolism, which play crucial roles in tumorigenesis, tumor progression, and treatment options. A better understanding of the underlying molecular mechanism of ferroptosis has shed light on the current findings of ferroptosis-based nanodrug targeting strategies, such as driving ferroptosis in tumor cells and the tumor microenvironment, emerging combination therapy and against multidrug resistance. Furthermore, this review highlights the challenge and perspective of a ferroptosis-driven nanodrug delivery system for CRC-targeted therapy.

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