Ferroptosis: Mechanisms and Links with Diseases

Overview

Journal Signal Transduct Target Ther

Specialties Cell Biology
Pharmacology

Date 2021 Feb 4

PMID 33536413

Citations 398

Authors

Hong-Fa Yan

Ting Zou

Qing-Zhang Tuo

Shuo Xu

Hua Li

Abdel Ali Belaidi

Peng Lei

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids, which can be prevented by iron chelators (e.g., deferiprone, deferoxamine) and small lipophilic antioxidants (e.g., ferrostatin, liproxstatin). This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association with several pathways, including iron, lipid, and cysteine metabolism. We have further discussed the contribution of ferroptosis to the pathogenesis of several diseases such as cancer, ischemia/reperfusion, and various neurodegenerative diseases (e.g., Alzheimer's disease and Parkinson's disease), and evaluated the therapeutic applications of ferroptosis inhibitors in clinics.

Citing Articles

Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer.

Ma S, Wang Z, Xiong Z, Ge Y, Xu M, Zhang J Signal Transduct Target Ther. 2025; 10(1):87.

PMID: 40082405 PMC: 11906896. DOI: 10.1038/s41392-025-02170-6.

Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment.

Rostami Ravari N, Sadri F, Mahdiabadi M, Mohammadi Y, Ourang Z, Rezaei Z Front Cell Dev Biol. 2025; 13:1522873.

PMID: 40078365 PMC: 11897296. DOI: 10.3389/fcell.2025.1522873.

ADAM17/PTGS2 Facilitates Pulmonary Fibrosis by Regulating Ferroptosis.

Yan S, Zhao Y, Xu W, Zhang J, Zhang Y, Liu B J Cell Mol Med. 2025; 29(5):e70466.

PMID: 40077919 PMC: 11903495. DOI: 10.1111/jcmm.70466.

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Varga D, Szentirmai A, Szarka A Molecules. 2025; 30(5).

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Chen S, Shyu I, Chi J Cancers (Basel). 2025; 17(5).

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