The Expression of ASAP3 and NOTCH3 and the Clinicopathological Characteristics of Adult Glioma Patients

is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of  and and their relationships on prognosis. The Oncomine, TIMER, and Gene Expression Profiling Interactive Analysis databases were used to investigate expression. Immunohistochemistry was used to assess the levels of  and expressions. The effects of  and on prognosis were assessed using survival analysis. The results revealed that the amount of mRNA in gliomas was much higher than in normal tissue ( < 0.01). Glioma patients with high mRNA expression had a worse overall survival and progression-free survival. overexpression is directly associated with the NOTCH signaling system. Immunohistochemistry revealed that  and were overexpressed in glioblastomas (GBMs). expression was associated with age, recurrence, tumor resection, postoperative chemoradiotherapy, World Health Organization (WHO) grade, and expression.  expression was related to the isocitrate dehydrogenase-1 mutation in low-grade glioma. Gender, local recurrence, tumor resection, postoperative radio-chemotherapy, WHO grade, recurrence, and expression were all associated with  expression.  was shown to be positively associated with ( = 0.337, = 0.000). Therefore, and  as oncogene factors have the potential to be prognostic biomarkers and therapeutic targets in adult glioma.