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The Varied Roles of Notch in Cancer

Overview
Journal Annu Rev Pathol
Publisher Annual Reviews
Specialty Pathology
Date 2016 Dec 14
PMID 27959635
Citations 362
Authors
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Abstract

Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.

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References
1.
Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C . Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov. 2014; 4(10):1154-67. PMC: 4184927. DOI: 10.1158/2159-8290.CD-13-0830. View

2.
Andrawes M, Xu X, Liu H, Ficarro S, Marto J, Aster J . Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013; 288(35):25477-25489. PMC: 3757209. DOI: 10.1074/jbc.M113.454850. View

3.
Leong K, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I . Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med. 2007; 204(12):2935-48. PMC: 2118507. DOI: 10.1084/jem.20071082. View

4.
Arnett K, Hass M, McArthur D, Ilagan M, Aster J, Kopan R . Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010; 17(11):1312-7. PMC: 3024583. DOI: 10.1038/nsmb.1938. View

5.
Dang C, Le A, Gao P . MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009; 15(21):6479-83. PMC: 2783410. DOI: 10.1158/1078-0432.CCR-09-0889. View