A Beginner's Guide to T Cell Development

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2022 Nov 14

PMID 36374448

Authors

Remy Bosselut

Affiliations

Soon will be listed here.

Abstract

T lymphocytes (T cells) are essential components of the adaptive immune system; they serve multiple functions in responses to pathogens and to ensure immune homeostasis. Written for readers first entering this field of study, this chapter is a brief overview of the development of T cells in the thymus, from the entry of thymus-settling bone marrow-derived precursors to the egress of mature T cells. Surveyed topics include the differentiation and expansion of early precursors, the generation of the T cell antigen receptor repertoire, the selection of αβ T cell precursors, and their acquisition of functional competency.

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