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Fibroblasts and Macrophages of Mice with the Chediak-Higashi-like Syndrome Have Microtubules and Actin Cables

Overview
Journal J Cell Biol
Specialty Cell Biology
Date 1978 Nov 1
PMID 363727
Citations 12
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Abstract

Cells of the beige mouse contain abnormally large lysosomes and show enhanced capping of concanavalin A. It has been suggested that these phenomena may be secondary to a defect in microtubule polymerization. We have examined the cytoskeleton of beige mouse cells by indirect immunofluorescence and find the number and distribution of microtubules and actin cables to be indistinguishable from those of normal control cells.

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