Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development

Overview

Journal Cancer Res

Specialty Oncology

Date 2024 Feb 5

PMID 38315779

Authors

Lior Goldberg

Eric R Haas

Ryan Urak

Vibhuti Vyas

Khyatiben V Pathak

Krystine Garcia-Mansfield

Patrick Pirrotte

Jyotsana Singhal

James L Figarola

Ibrahim Aldoss

Stephen J Forman

Xiuli Wang

Affiliations

Soon will be listed here.

Abstract

Significance: The spatiotemporal immunometabolic landscape of CD19-targeted CAR T cells from patients reveals metabolic adaptations in specific microenvironments that can be exploited to maximize the therapeutic efficacy of CAR T cells.

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