Macrophages in Health and Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2022 Nov 11

PMID 36368305

Authors

Matthew D Park

Aymeric Silvin

Florent Ginhoux

Miriam Merad

Affiliations

Soon will be listed here.

Abstract

The heterogeneity of tissue macrophages, in health and in disease, has become increasingly transparent over the last decade. But with the plethora of data comes a natural need for organization and the design of a conceptual framework for how we can better understand the origins and functions of different macrophages. We propose that the ontogeny of a macrophage-beyond its fundamental derivation as either embryonically or bone marrow-derived, but rather inclusive of the course of its differentiation, amidst steady-state cues, disease-associated signals, and time-constitutes a critical piece of information about its contribution to homeostasis or the progression of disease.

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