Advances in Biodegradable Soft Robots

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Nov 11

PMID 36365570

Authors

Jiwon Kim

Harim Park

ChangKyu Yoon

Affiliations

Soon will be listed here.

Abstract

Biodegradable soft robots have been proposed for a variety of intelligent applications in soft robotics, flexible electronics, and bionics. Biodegradability offers an extraordinary functional advantage to soft robots for operations accompanying smart shape transformation in response to external stimuli such as heat, pH, and light. This review primarily surveyed the current advanced scientific and engineering strategies for integrating biodegradable materials within stimuli-responsive soft robots. It also focused on the fabrication methodologies of multiscale biodegradable soft robots, and highlighted the role of biodegradable soft robots in enhancing the multifunctional properties of drug delivery capsules, biopsy tools, smart actuators, and sensors. Lastly, the current challenges and perspectives on the future development of intelligent soft robots for operation in real environments were discussed.

Citing Articles

Organic Ink Multi-Material 3D Printing of Sustainable Soft Systems.

Heiden A, Schardax M, Huttenberger M, Preninger D, Mao G, Schiller D Adv Mater. 2024; 37(4):e2409403.

PMID: 39533489 PMC: 11775878. DOI: 10.1002/adma.202409403.

A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials-Recent Advances and Future Perspectives.

Balcerak-Wozniak A, Dzwonkowska-Zarzycka M, Kabatc-Borcz J Materials (Basel). 2024; 17(17).

PMID: 39274645 PMC: 11396725. DOI: 10.3390/ma17174255.

A review on self-healing featured soft robotics.

Islam M, Talukder L, Al M, Sarker S, Muyeen S, Das P Front Robot AI. 2023; 10:1202584.

PMID: 37953963 PMC: 10637358. DOI: 10.3389/frobt.2023.1202584.

Bioinspired robots can foster nature conservation.

Chellapurath M, Khandelwal P, Schulz A Front Robot AI. 2023; 10:1145798.

PMID: 37920863 PMC: 10619165. DOI: 10.3389/frobt.2023.1145798.

A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications.

Wang Y, Chen J, Su G, Mei J, Li J Micromachines (Basel). 2023; 14(9).

PMID: 37763873 PMC: 10537272. DOI: 10.3390/mi14091710.

References

Kim K, Dean D, Mikos A, Fisher J . Effect of initial cell seeding density on early osteogenic signal expression of rat bone marrow stromal cells cultured on cross-linked poly(propylene fumarate) disks. Biomacromolecules. 2009; 10(7):1810-7. PMC: 3655530. DOI: 10.1021/bm900240k. View

Hosseinidoust Z, Mostaghaci B, Yasa O, Park B, Singh A, Sitti M . Bioengineered and biohybrid bacteria-based systems for drug delivery. Adv Drug Deliv Rev. 2016; 106(Pt A):27-44. DOI: 10.1016/j.addr.2016.09.007. View

Zhou M, Yu D . Cartilage tissue engineering using PHBV and PHBV/Bioglass scaffolds. Mol Med Rep. 2014; 10(1):508-14. DOI: 10.3892/mmr.2014.2145. View

Bunea A, Taboryski R . Recent Advances in Microswimmers for Biomedical Applications. Micromachines (Basel). 2020; 11(12). PMC: 7760273. DOI: 10.3390/mi11121048. View

Gogele C, Muller S, Belov S, Pradel A, Wiltzsch S, Lenhart A . Biodegradable Poly(D-L-lactide-co-glycolide) (PLGA)-Infiltrated Bioactive Glass (CAR12N) Scaffolds Maintain Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering. Cells. 2022; 11(9). PMC: 9100331. DOI: 10.3390/cells11091577. View

Lovald S, Khraishi T, Wagner J, Baack B . Mechanical design optimization of bioabsorbable fixation devices for bone fractures. J Craniofac Surg. 2009; 20(2):389-98. DOI: 10.1097/SCS.0b013e31819b96fb. View

Stewart S, Dominguez-Robles J, Donnelly R, Larraneta E . Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications. Polymers (Basel). 2019; 10(12). PMC: 6401754. DOI: 10.3390/polym10121379. View

Stamou A, Iatrou H, Tsitsilianis C . NIPAm-Based Modification of Poly(L-lysine): A pH-Dependent LCST-Type Thermo-Responsive Biodegradable Polymer. Polymers (Basel). 2022; 14(4). PMC: 8962975. DOI: 10.3390/polym14040802. View

Kobayashi K, Yoon C, Oh S, Pagaduan J, Gracias D . Biodegradable Thermomagnetically Responsive Soft Untethered Grippers. ACS Appl Mater Interfaces. 2018; 11(1):151-159. DOI: 10.1021/acsami.8b15646. View

10.

Capuana E, Lopresti F, Ceraulo M, La Carrubba V . Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications. Polymers (Basel). 2022; 14(6). PMC: 8955974. DOI: 10.3390/polym14061153. View

11.

Panchal S, Vasava D . Biodegradable Polymeric Materials: Synthetic Approach. ACS Omega. 2020; 5(9):4370-4379. PMC: 7066571. DOI: 10.1021/acsomega.9b04422. View

12.

Malachowski K, Breger J, Kwag H, Wang M, Fisher J, Selaru F . Stimuli-responsive theragrippers for chemomechanical controlled release. Angew Chem Int Ed Engl. 2014; 53(31):8045-8049. PMC: 4315180. DOI: 10.1002/anie.201311047. View

13.

Ahn S, Kasi R, Kim S, Sharma N, Zhou Y . Stimuli-responsive polymer gels. Soft Matter. 2020; 4(6):1151-1157. DOI: 10.1039/b714376a. View

14.

Wei T, Liu J, Li D, Chen S, Zhang Y, Li J . Development of Magnet-Driven and Image-Guided Degradable Microrobots for the Precise Delivery of Engineered Stem Cells for Cancer Therapy. Small. 2020; 16(41):e1906908. DOI: 10.1002/smll.201906908. View

15.

Zhang Y, Khademhosseini A . Advances in engineering hydrogels. Science. 2017; 356(6337). PMC: 5841082. DOI: 10.1126/science.aaf3627. View

16.

Cai Z, Wan Y, Becker M, Long Y, Dean D . Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications. Biomaterials. 2019; 208:45-71. DOI: 10.1016/j.biomaterials.2019.03.038. View

17.

Fusco S, Sakar M, Kennedy S, Peters C, Bottani R, Starsich F . An integrated microrobotic platform for on-demand, targeted therapeutic interventions. Adv Mater. 2014; 26(6):952-7. DOI: 10.1002/adma.201304098. View

18.

Pryadko A, Botvin V, Mukhortova Y, Pariy I, Wagner D, Laktionov P . Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications. Polymers (Basel). 2022; 14(3). PMC: 8839593. DOI: 10.3390/polym14030529. View

19.

Yue K, Trujillo-de Santiago G, Alvarez M, Tamayol A, Annabi N, Khademhosseini A . Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 2015; 73:254-71. PMC: 4610009. DOI: 10.1016/j.biomaterials.2015.08.045. View

20.

Marquardt L, Day D, Sakiyama-Elbert S, Harkins A . Effects of borate-based bioactive glass on neuron viability and neurite extension. J Biomed Mater Res A. 2013; 102(8):2767-75. DOI: 10.1002/jbm.a.34944. View