Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of and Their Bioactivities

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Nov 11

PMID 36364215

Authors

Shi-Hui Lu

Hao-Jiang Zuo

Jing Huang

Ran Chen

Jia-Ping Pan

Xiu-Xia Li

Affiliations

Soon will be listed here.

Abstract

The phytochemical study on the leaves of , which have been used as Ku-Ding-Cha, led to the isolation and identification of three new phenylethanoid glycosides and three new phenylmethanoid glycosides, named ligurobustosides R (), R (), R (), S (), S (), and S (), and five reported phenylethanoid glycosides (-). In the bioactivity test, ()-osmanthuside B () displayed strong fatty acid synthase (FAS) inhibitory activity (IC: 4.55 ± 0.35 μM) as the positive control orlistat (IC: 4.46 ± 0.13 μM), while ligurobustosides R () and S (), ligupurpuroside B (), -ligupurpuroside B (), ligurobustoside N (), osmanthuside D (), and ()-osmanthuside B () showed stronger ABTS radical scavenging activity (IC: 2.68 ± 0.05~4.86 ± 0.06 μM) than the positive control L-(+)-ascorbic acid (IC: 10.06 ± 0.19 μM). This research provided a theoretical basis for the leaves of as a tea with function in treating obesity and diabetes.

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