Monoterpenoid Glycosides from the Leaves of and Their Bioactivities

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jun 24

PMID 35744841

Authors

Shi-Hui Lu

Jing Huang

Hao-Jiang Zuo

Zhong-Bo Zhou

Cai-Yan Yang

Zu-Liang Huang

Affiliations

Soon will be listed here.

Abstract

The leaves of have been applied as Ku-Ding-Cha, a functional tea to clear heat, remove toxins, and treat obesity and diabetes, in Southwest China. The phytochemical research on the leaves of led to the isolation and identification of eight new monoterpenoid glycosides (-) and three known monoterpenoid glycosides (-). Compounds - were tested for the inhibitory activities on fatty acid synthase (FAS), -glucosidase, -amylase, and the antioxidant effects. Compound showed stronger FAS inhibitory activity (IC: 2.36 ± 0.10 μM) than the positive control orlistat (IC: 4.46 ± 0.13 μM), while compounds , , and displayed more potent ABTS radical scavenging activity (IC: 6.91 ± 0.10~9.41 ± 0.22 μM) than the positive control L-(+)-ascorbic acid (IC: 10.06 ± 0.19 μM). This study provided a theoretical basis for the leaves of as a functional tea to treat obesity.

Citing Articles

Monoterpenoid Glycosides from the Leaves of and Their Bioactivities (II).

Lu S, Li X, Zuo H, Li W, Pan J, Huang J Molecules. 2023; 28(21).

PMID: 37959693 PMC: 10647328. DOI: 10.3390/molecules28217274.

A New HPLC-UV Method Using Hydrolyzation with Sodium Hydroxide for Quantitation of --Hydroxycinnamic Acid and Total --Hydroxycinnamic Acid Esters in the Leaves of .

Lu S, Liang X, Nong X, Chen R, Li X Molecules. 2023; 28(14).

PMID: 37513183 PMC: 10383156. DOI: 10.3390/molecules28145309.

Seven New Phenylhexanoids with Antioxidant Activity from var. .

Huang J, Chen D, Liu M, Yu Y, Zhang Y, Huang J Molecules. 2023; 28(9).

PMID: 37175339 PMC: 10180102. DOI: 10.3390/molecules28093928.

Chemical Constituents from the Leaves of and Their Bioactivities.

Lu S, Zuo H, Huang J, Li W, Huang J, Li X Molecules. 2023; 28(1).

PMID: 36615556 PMC: 9822135. DOI: 10.3390/molecules28010362.

Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of and Their Bioactivities.

Lu S, Zuo H, Huang J, Chen R, Pan J, Li X Molecules. 2022; 27(21).

PMID: 36364215 PMC: 9657303. DOI: 10.3390/molecules27217390.

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