Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
Overview
Molecular Biology
Authors
Affiliations
Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury.
Different types of cell death and their interactions in myocardial ischemia-reperfusion injury.
Du B, Fu Q, Yang Q, Yang Y, Li R, Yang X Cell Death Discov. 2025; 11(1):87.
PMID: 40044643 PMC: 11883039. DOI: 10.1038/s41420-025-02372-5.
The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review.
Xie X, Huang M, Ma S, Xin Q, Wang Y, Hu L Noncoding RNA Res. 2025; 11:158-187.
PMID: 39896344 PMC: 11783329. DOI: 10.1016/j.ncrna.2024.12.009.
Identifying Pyroptosis-Hub Genes and Inflammation Cell Type-Related Genes in Ischemic Stroke.
Ge W, Cao L, Liu C, Wang H, Lu M, Chen Y Mol Neurobiol. 2025; .
PMID: 39798044 DOI: 10.1007/s12035-024-04647-x.
Chen S, Hao P, Liang Y, Cao Y, Han W, Sun S Neuropsychiatr Dis Treat. 2024; 20:2335-2346.
PMID: 39619494 PMC: 11608552. DOI: 10.2147/NDT.S485884.
LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation.
Fang L, Yu Z, Qian X, Fang H, Wang Y BMC Cardiovasc Disord. 2024; 24(1):651.
PMID: 39548367 PMC: 11568565. DOI: 10.1186/s12872-024-04251-w.