The Therapeutic Potential of Plant Polysaccharides in Metabolic Diseases

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2022 Nov 10

PMID 36355500

Authors

Xiao-Fang Wang

Xue Chen

Yong Tang

Jian-Ming Wu

Da-Lian Qin

Lu Yu

Chong-Lin Yu

Xiao-Gang Zhou

An-Guo Wu

Affiliations

Soon will be listed here.

Abstract

Plant polysaccharides (PPS) composed of more than 10 monosaccharides show high safety and various pharmacological activities, including immunoregulatory, antitumor, antioxidative, antiaging, and other effects. In recent years, emerging evidence has indicated that many PPS are beneficial for metabolic diseases, such as cardiovascular disease (CVD), diabetes, obesity, and neurological diseases, which are usually caused by the metabolic disorder of fat, sugar, and protein. In this review, we introduce the common characteristics and functional activity of many representative PPS, emphasize the common risks and molecular mechanism of metabolic diseases, and discuss the pharmacological activity and mechanism of action of representative PPS obtained from plants including , , pumpkin, , , , , , and tea in metabolic diseases. Finally, this review will provide directions and a reference for future research and for the development of PPS into potential drugs for the treatment of metabolic diseases.

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