A Cross-sectional Study on the Effect of Dietary Zinc Intake on the Relationship Between Serum Vitamin D and HOMA-IR

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Nov 10

PMID 36352900

Authors

Biao Hu

Zheng-Yang Lin

Yuan Cai

Yue-Xin Sun

Shu-Qi Yang

Jiang-Long Guo

Shi Zhang

Dong-Lin Sun

Affiliations

Soon will be listed here.

Abstract

Introduction: Serum vitamin D concentration is associated with the risk of insulin resistance. Zinc has also been reported to be associated with a lower risk of insulin resistance. In addition, zinc is an essential cofactor in the activation of vitamin D. However, the effect of dietary zinc intake on the relationship between vitamin D and insulin resistance risk has not been fully studied. Therefore, we designed this cross-sectional study to assess the impact of changes in zinc intake on the relationship between vitamin D and insulin resistance risk.

Study Design And Methods: This study analyzed data from the national Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, involving 9,545 participants. Participants were stratified by zinc intake category (low zinc intake <9.58 mg/ day; High zinc intake: ≥9.58 mg/ day).

Results: In this cross-sectional study, serum vitamin D levels were independently associated with the risk of insulin resistance in both the low and high Zinc intakes (β: -0.26, 95%Cl: -0.56~0.04 vs. β: -0.56, 95%Cl: -1.01~-0.11). In addition, this association was influenced by different dietary zinc intakes (interaction < 0.05).

Conclusions: Our results suggest that zinc intake may influence the association between serum vitamin D and the risk of insulin resistance. Further randomized controlled trials are needed to provide more evidence of this finding.

Citing Articles

Association between dietary folate intake and severe abdominal aorta calcification in adults: A cross-sectional analysis of the national health and nutrition examination survey.

Zhang K, Chen J, Chen B, Han Y, Cai T, Zhao J Diab Vasc Dis Res. 2024; 21(2):14791641241246555.

PMID: 38597693 PMC: 11015784. DOI: 10.1177/14791641241246555.

References

Gammoh N, Rink L . Zinc in Infection and Inflammation. Nutrients. 2017; 9(6). PMC: 5490603. DOI: 10.3390/nu9060624. View

Foster E, Lee C, Imamura F, Hollidge S, Westgate K, Venables M . Validity and reliability of an online self-report 24-h dietary recall method (Intake24): a doubly labelled water study and repeated-measures analysis. J Nutr Sci. 2019; 8:e29. PMC: 6722486. DOI: 10.1017/jns.2019.20. View

Petersen M, Shulman G . Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018; 98(4):2133-2223. PMC: 6170977. DOI: 10.1152/physrev.00063.2017. View

Samadi A, Isikhan S, Tinkov A, Lay I, Dosa M, Skalny A . Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. Clin Nutr. 2019; 39(6):1849-1856. DOI: 10.1016/j.clnu.2019.07.026. View

Barman S, Srinivasan K . Zinc supplementation alleviates hyperglycemia and associated metabolic abnormalities in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2016; 94(12):1356-1365. DOI: 10.1139/cjpp-2016-0084. View

Story M . Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer. Biochimie. 2021; 187:94-109. PMC: 8166046. DOI: 10.1016/j.biochi.2021.05.013. View

Vashum K, McEvoy M, Milton A, Islam M, Hancock S, Attia J . Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the Hunter Community Study. PLoS One. 2014; 9(1):e83944. PMC: 3885544. DOI: 10.1371/journal.pone.0083944. View

Nagashima T, Shirakawa H, Nakagawa T, Kaneko S . Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism. Sci Rep. 2016; 6:26375. PMC: 4873813. DOI: 10.1038/srep26375. View

Burnett B, Pillai L, Bitto A, Squadrito F, Levy R . Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women. Int J Womens Health. 2011; 3:139-50. PMC: 3140810. DOI: 10.2147/IJWH.S19309. View

10.

Gandhe M, Jain K, Gandhe S . Evaluation of 25(OH) Vitamin D3 with Reference to Magnesium Status and Insulin Resistance in T2DM. J Clin Diagn Res. 2014; 7(11):2438-41. PMC: 3879824. DOI: 10.7860/JCDR/2013/6578.3568. View

11.

Fain J . NHANES. Diabetes Educ. 2017; 43(2):151. DOI: 10.1177/0145721717698651. View

12.

Santucci N, Alkhouri R, Baker R, Baker S . Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2014; 59(4):455-7. DOI: 10.1097/MPG.0000000000000477. View

13.

Chailurkit L, Aekplakorn W, Ongphiphadhanakul B . The association between vitamin D status and type 2 diabetes in a Thai population, a cross-sectional study. Clin Endocrinol (Oxf). 2012; 77(5):658-64. DOI: 10.1111/j.1365-2265.2012.04422.x. View

14.

Mendes Garrido Abregu F, Gobetto M, Juriol L, Caniffi C, Elesgaray R, Tomat A . Developmental programming of vascular dysfunction by prenatal and postnatal zinc deficiency in male and female rats. J Nutr Biochem. 2018; 56:89-98. DOI: 10.1016/j.jnutbio.2018.01.013. View

15.

Ahluwalia N, Dwyer J, Terry A, Moshfegh A, Johnson C . Update on NHANES Dietary Data: Focus on Collection, Release, Analytical Considerations, and Uses to Inform Public Policy. Adv Nutr. 2016; 7(1):121-34. PMC: 4717880. DOI: 10.3945/an.115.009258. View

16.

Erdonmez D, Hatun S, Cizmecioglu F, Keser A . No relationship between vitamin D status and insulin resistance in a group of high school students. J Clin Res Pediatr Endocrinol. 2011; 3(4):198-201. PMC: 3245493. DOI: 10.4274/jcrpe.507. View

17.

Choi S, Liu X, Pan Z . Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacol Sin. 2018; 39(7):1120-1132. PMC: 6289396. DOI: 10.1038/aps.2018.25. View

18.

Zipf G, Chiappa M, Porter K, Ostchega Y, Lewis B, Dostal J . National health and nutrition examination survey: plan and operations, 1999-2010. Vital Health Stat 1. 2014; (56):1-37. View

19.

Da Silva T, Hiller C, Gai Z, Kullak-Ublick G . Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016; 163:77-87. DOI: 10.1016/j.jsbmb.2016.04.006. View

20.

Xu Z, Gong R, Luo G, Wang M, Li D, Chen Y . Association between vitamin D3 levels and insulin resistance: a large sample cross-sectional study. Sci Rep. 2022; 12(1):119. PMC: 8741779. DOI: 10.1038/s41598-021-04109-7. View